N-(3-{1-(2-amino-ethyl)-3-[1-(3-methyl-1-methylcarbamoyl-butylcarbamoyl)-2-phenyl-ethyl]-ureido}-propyl)-N'-(4-methoxy-3-methylcarbamoyl-phenyl)-oxalamide

Base Information

Chemical Name:N-(3-{1-(2-amino-ethyl)-3-[1-(3-methyl-1-methylcarbamoyl-butylcarbamoyl)-2-phenyl-ethyl]-ureido}-propyl)-N'-(4-methoxy-3-methylcarbamoyl-phenyl)-oxalamide
CAS No.:349649-38-3
Molecular Formula:C₃₃H₄₈N₈O₇
Molecular Weight:668.794
Hs Code.:

<i>N</i>-(3-{1-(2-amino-ethyl)-3-[1-(3-methyl-1-methylcarbamoyl-butylcarbamoyl)-2-phenyl-ethyl]-ureido}-propyl)-<i>N</i>'-(4-methoxy-3-methylcarbamoyl-phenyl)-oxalamide

Synonyms:N-(3-{1-(2-amino-ethyl)-3-[1-(3-methyl-1-methylcarbamoyl-butylcarbamoyl)-2-phenyl-ethyl]-ureido}-propyl)-N'-(4-methoxy-3-methylcarbamoyl-phenyl)-oxalamide

Suppliers and Price of N-(3-{1-(2-amino-ethyl)-3-[1-(3-methyl-1-methylcarbamoyl-butylcarbamoyl)-2-phenyl-ethyl]-ureido}-propyl)-N'-(4-methoxy-3-methylcarbamoyl-phenyl)-oxalamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(3-{1-(2-amino-ethyl)-3-[1-(3-methyl-1-methylcarbamoyl-butylcarbamoyl)-2-phenyl-ethyl]-ureido}-propyl)-N'-(4-methoxy-3-methylcarbamoyl-phenyl)-oxalamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(3-{1-(2-amino-ethyl)-3-[1-(3-methyl-1-methylcarbamoyl-butylcarbamoyl)-2-phenyl-ethyl]-ureido}-propyl)-N'-(4-methoxy-3-methylcarbamoyl-phenyl)-oxalamide

There total 7 articles about N-(3-{1-(2-amino-ethyl)-3-[1-(3-methyl-1-methylcarbamoyl-butylcarbamoyl)-2-phenyl-ethyl]-ureido}-propyl)-N'-(4-methoxy-3-methylcarbamoyl-phenyl)-oxalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 349649-37-2
(2-{1-{3-[(4-Methoxy-3-methylcarbamoyl-phenylaminooxalyl)-amino]-propyl}-3-[(S)-1-((S)-3-methyl-1-methylcarbamoyl-butylcarbamoyl)-2-phenyl-ethyl]-ureido}-ethyl)-carbamic acid tert-butyl ester

: 349649-38-3
N-(3-{1-(2-amino-ethyl)-3-[1-(3-methyl-1-methylcarbamoyl-butylcarbamoyl)-2-phenyl-ethyl]-ureido}-propyl)-N'-(4-methoxy-3-methylcarbamoyl-phenyl)-oxalamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 2.5h;
DOI:10.1021/ja010220s

Reference yield:

: 5-amino-2-methoxy-N-methylbenzamide hydrochloride

: 349649-38-3
N-(3-{1-(2-amino-ethyl)-3-[1-(3-methyl-1-methylcarbamoyl-butylcarbamoyl)-2-phenyl-ethyl]-ureido}-propyl)-N'-(4-methoxy-3-methylcarbamoyl-phenyl)-oxalamide

Guidance literature:: Multi-step reaction with 7 steps

1: 91 percent / Et₃N / CH₂Cl₂ / 0.25 h

2: 44 percent / CH₂Cl₂ / 48 h

3: 52 percent / Cs₂CO₃ / dimethylformamide / 20 h

4: 98 percent / PhSH; K₂CO₃ / dimethylformamide / 5.5 h

5: 82 percent / Et₃N / CH₂Cl₂ / 6.5 h

6: 86 percent / methanol / 18.5 h

7: 60 percent / TFA / CH₂Cl₂ / 2.5 h

With potassium carbonate; caesium carbonate; thiophenol; triethylamine; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja010220s

Reference yield:

: 349649-33-8
N-(4-methoxy-3-methylcarbamoyl-phenyl)-oxalamic acid ethyl ester

: 349649-38-3
N-(3-{1-(2-amino-ethyl)-3-[1-(3-methyl-1-methylcarbamoyl-butylcarbamoyl)-2-phenyl-ethyl]-ureido}-propyl)-N'-(4-methoxy-3-methylcarbamoyl-phenyl)-oxalamide

Guidance literature:: Multi-step reaction with 6 steps

1: 44 percent / CH₂Cl₂ / 48 h

2: 52 percent / Cs₂CO₃ / dimethylformamide / 20 h

3: 98 percent / PhSH; K₂CO₃ / dimethylformamide / 5.5 h

4: 82 percent / Et₃N / CH₂Cl₂ / 6.5 h

5: 86 percent / methanol / 18.5 h

6: 60 percent / TFA / CH₂Cl₂ / 2.5 h

With potassium carbonate; caesium carbonate; thiophenol; triethylamine; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja010220s