(3aR,5s,6aS)-5-[(4'-ethoxybiphenyl-3-yl)oxy]octahydrocyclopenta[c]pyrrole

Base Information

Chemical Name:(3aR,5s,6aS)-5-[(4'-ethoxybiphenyl-3-yl)oxy]octahydrocyclopenta[c]pyrrole
CAS No.:1256240-29-5
Molecular Formula:C₂₁H₂₅NO₂
Molecular Weight:323.435
Hs Code.:

Synonyms:(3aR,5s,6aS)-5-[(4'-ethoxybiphenyl-3-yl)oxy]octahydrocyclopenta[c]pyrrole

Suppliers and Price of (3aR,5s,6aS)-5-[(4'-ethoxybiphenyl-3-yl)oxy]octahydrocyclopenta[c]pyrrole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3aR,5s,6aS)-5-[(4'-ethoxybiphenyl-3-yl)oxy]octahydrocyclopenta[c]pyrrole

Chemical Property:

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Technology Process of (3aR,5s,6aS)-5-[(4'-ethoxybiphenyl-3-yl)oxy]octahydrocyclopenta[c]pyrrole

There total 5 articles about (3aR,5s,6aS)-5-[(4'-ethoxybiphenyl-3-yl)oxy]octahydrocyclopenta[c]pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1256240-28-4
tert-butyl (3aR,5s,6aS)-5-[(4'-ethoxybiphenyl-3-yl)oxy]hexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate

: 1256240-29-5
(3aR,5s,6aS)-5-[(4'-ethoxybiphenyl-3-yl)oxy]octahydrocyclopenta[c]pyrrole

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 912563-45-2
tert-butyl (3aR,5r,6aS)-5-hydroxy-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-2-carboxylate

: 1256240-29-5
(3aR,5s,6aS)-5-[(4'-ethoxybiphenyl-3-yl)oxy]octahydrocyclopenta[c]pyrrole

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / N,N-dimethyl-formamide / 15 h / 90 °C

2: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; tetrahydrofuran / 15 h / 75 °C / Inert atmosphere

3: hydrogenchloride / dichloromethane; 1,4-dioxane / 2 h / 20 °C

With hydrogenchloride; sodium hydride; caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 591-18-4
1-Bromo-3-iodobenzene

: 1256240-29-5
(3aR,5s,6aS)-5-[(4'-ethoxybiphenyl-3-yl)oxy]octahydrocyclopenta[c]pyrrole

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / N,N-dimethyl-formamide / 15 h / 90 °C

2: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; tetrahydrofuran / 15 h / 75 °C / Inert atmosphere

3: hydrogenchloride / dichloromethane; 1,4-dioxane / 2 h / 20 °C

With hydrogenchloride; sodium hydride; caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;