2-Methoxy-6-<2-(4'-phenylthio)phenethyl>pyridine-3-carboxylic acid

Base Information

• Chemical Name: 2-Methoxy-6-<2-(4'-phenylthio)phenethyl>pyridine-3-carboxylic acid
• CAS No.: 72918-11-7
• Molecular Formula: C₂₁H₁₉NO₃S
• Molecular Weight: 365.453
• Mol file: 72918-11-7.mol

Synonyms:2-Methoxy-6-<2-(4'-phenylthio)phenethyl>pyridine-3-carboxylic acid

Chemical Property of 2-Methoxy-6-<2-(4'-phenylthio)phenethyl>pyridine-3-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2-Methoxy-6-<2-(4'-phenylthio)phenethyl>pyridine-3-carboxylic acid

There total 1 articles about 2-Methoxy-6-<2-(4'-phenylthio)phenethyl>pyridine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

1-phenylthio-4-chloromethyl-benzene (1208-87-3) + 2-Methoxy-6-methylpyridine-3-carboxylic acid (72918-10-6) → 1,2-Bis<4-(phenylthio)phenyl>ethane (72918-16-2) + 2-Methoxy-6-<2-(4'-phenylthio)phenethyl>pyridine-3-carboxylic acid (72918-11-7)

Guidance literature:

With lithium diisopropyl amide; Multistep reaction; 1.) THF, hexane, -78 deg C, 30 min, 2.) RT, 5 h;

DOI:10.1021/jo01296a002

Reference yield: 94.0%

2-Methoxy-6-<2-(4'-phenylthio)phenethyl>pyridine-3-carboxylic acid (72918-11-7) → 6-<2-(4'-Phenylthio)phenethyl>-2-pyridone-3-carboxylic acid (72918-12-8)

Guidance literature:

With trimethylsilyl iodide; In chloroform; for 18h; Ambient temperature;

DOI:10.1021/jo01296a002

Reference yield:

2-Methoxy-6-<2-(4'-phenylthio)phenethyl>pyridine-3-carboxylic acid (72918-11-7) → n-Hexadecyl 2-methoxy-6-<2-(4'-phenylthio)phenethyl>-2-pyridine-3-carboxylate (72918-13-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 94 percent / Iodotrimethylsilane / CHCl₃ / 18 h / Ambient temperature

2: 60 percent / hexamethylphosphoric acid triamide / 24 h / 60 °C

3: 25 percent / Potassium carbonate / dimethylformamide / 18 h / Ambient temperature

With trimethylsilyl iodide; potassium carbonate; In N,N,N,N,N,N-hexamethylphosphoric triamide; chloroform; N,N-dimethyl-formamide;

DOI:10.1021/jo01296a002

upstream raw materials:

1-phenylthio-4-chloromethyl-benzene

2-Methoxy-6-methylpyridine-3-carboxylic acid

Downstream raw materials:

6-<2-(4'-Phenylthio)phenethyl>-2-pyridone-3-carboxylic acid

n-Hexadecyl 2-methoxy-6-<2-(4'-phenylthio)phenethyl>-2-pyridine-3-carboxylate

n-Hexadecyl 6-<2-(4'-phenylthio)phenethyl>-2-pyridone-3-carboxylate

n-Hexadecyl 6-<2-(4'-phenylthio)phenethyl>-1-methyl-2-pyridone-3-carboxylate