diethyl [[4-(2-methoxyphenyl)-4-oxobut-2-yn-1-yl](methyl)amino](propa-1,2-dien-1-yl)malonate

Base Information

Chemical Name:diethyl [[4-(2-methoxyphenyl)-4-oxobut-2-yn-1-yl](methyl)amino](propa-1,2-dien-1-yl)malonate
CAS No.:1400553-94-7
Molecular Formula:C₂₂H₂₅NO₆
Molecular Weight:399.444
Hs Code.:

Synonyms:diethyl [[4-(2-methoxyphenyl)-4-oxobut-2-yn-1-yl](methyl)amino](propa-1,2-dien-1-yl)malonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of diethyl [[4-(2-methoxyphenyl)-4-oxobut-2-yn-1-yl](methyl)amino](propa-1,2-dien-1-yl)malonate

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Technology Process of diethyl [[4-(2-methoxyphenyl)-4-oxobut-2-yn-1-yl](methyl)amino](propa-1,2-dien-1-yl)malonate

There total 2 articles about diethyl [[4-(2-methoxyphenyl)-4-oxobut-2-yn-1-yl](methyl)amino](propa-1,2-dien-1-yl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: diethyl [methyl(prop-2-yn-1-yl)amino](propa-1,2-dien-1-yl)malonate

: 21615-34-9
2-Methoxybenzoyl chloride

: 1400553-94-7
diethyl [[4-(2-methoxyphenyl)-4-oxobut-2-yn-1-yl](methyl)amino](propa-1,2-dien-1-yl)malonate

Guidance literature:: With copper(l) iodide; dichlorobis(tri-O-tolylphosphine)palladium; triethylamine; In tetrahydrofuran; at 20 ℃; Inert atmosphere;
DOI:10.1021/jo301501r

Reference yield:

: 2568-61-8
N-methyl-N,N-dipropargylamine

: 1400553-94-7
diethyl [[4-(2-methoxyphenyl)-4-oxobut-2-yn-1-yl](methyl)amino](propa-1,2-dien-1-yl)malonate

Guidance literature:: Multi-step reaction with 2 steps

1: copper(II) hexafluoroacetylacetonate / toluene / 1.5 h / Reflux

2: copper(l) iodide; dichlorobis(tri-O-tolylphosphine)palladium; triethylamine / tetrahydrofuran / 20 °C / Inert atmosphere

With copper(l) iodide; dichlorobis(tri-O-tolylphosphine)palladium; copper(II) hexafluoroacetylacetonate; triethylamine; In tetrahydrofuran; toluene; 2: |Sonogashira Cross-Coupling;
DOI:10.1021/jo301501r