2-Hydroxy-5-nitrobenzohydrazide

Base Information

• Chemical Name: 2-Hydroxy-5-nitrobenzohydrazide
• CAS No.: 946-32-7
• Molecular Formula: C₇H₇N₃O₄
• Molecular Weight: 197.15
• DSSTox Substance ID: DTXSID201260140
• Nikkaji Number: J1.449.110D
• Mol file: 946-32-7.mol

Synonyms:2-hydroxy-5-nitrobenzohydrazide;946-32-7;5-nitrosalicylhydrazide;5-Nitrosalicylic hydrazide;SCHEMBL1637466;IFROEJRAWJNALM-UHFFFAOYSA-N;DTXSID201260140;AKOS024377752;Benzoic acid, 2-hydroxy-5-nitro-, hydrazide;EN300-91875

Chemical Property of 2-Hydroxy-5-nitrobenzohydrazide

Chemical Property:

• XLogP3: 1.3
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 197.04365571
• Heavy Atom Count: 14
• Complexity: 240

Purity/Quality:

97% ^*data from raw suppliers

2-hydroxy-5-nitrobenzohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC(=C(C=C1[N+](=O)[O-])C(=O)NN)O

Technology Process of 2-Hydroxy-5-nitrobenzohydrazide

There total 3 articles about 2-Hydroxy-5-nitrobenzohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-hydroxy-5-nitrobenzoate (17302-46-4) → 2-hydroxy-5-nitrobenzhydrazide (946-32-7)

Guidance literature:

With methanol; hydrazine hydrate;

Reference yield:

methyl salicylate (119-36-8,8024-54-2) → 2-hydroxy-5-nitrobenzhydrazide (946-32-7)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; aqueous HNO₃

2: methanol; aqueous N₂H₄

With methanol; nitric acid; hydrazine hydrate; acetic acid;

Reference yield:

→ 2-hydroxy-5-nitrobenzhydrazide (946-32-7)

Guidance literature:

entspr. Me-Ester, N2H4*H2O;

upstream raw materials:

methyl 2-hydroxy-5-nitrobenzoate

methyl salicylate

Downstream raw materials:

2-hydroxy-5-nitro-benzoic acid methylenehydrazide

N-acetyl-5-nitrosalicylhydrazine

N'-(hex-5-en-2-yl)-2-hydroxy-5-nitrobenzohydrazide

C₁₅H₁₀N₄O₅