2-(4-(3-amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)piperidine-1-carbonyl)-3-cyclopropylacrylonitrile

Base Information

Chemical Name:2-(4-(3-amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)piperidine-1-carbonyl)-3-cyclopropylacrylonitrile
CAS No.:1413943-82-4
Molecular Formula:C₃₀H₂₈N₆O₂
Molecular Weight:504.591
Hs Code.:

Synonyms:2-(4-(3-amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)piperidine-1-carbonyl)-3-cyclopropylacrylonitrile

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Chemical Property of 2-(4-(3-amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)piperidine-1-carbonyl)-3-cyclopropylacrylonitrile

Chemical Property:

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Technology Process of 2-(4-(3-amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)piperidine-1-carbonyl)-3-cyclopropylacrylonitrile

There total 11 articles about 2-(4-(3-amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)piperidine-1-carbonyl)-3-cyclopropylacrylonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1413943-85-7
3-(4-(3-amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)piperidin-1-yl)-3-oxopropanenitrile

: 1489-69-6
Cyclopropanecarboxaldehyde

: 1413943-82-4
2-(4-(3-amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)piperidine-1-carbonyl)-3-cyclopropylacrylonitrile

Guidance literature:: With piperidine; In methanol; at 20 ℃; for 1.5h;

Reference yield:

: 10314-98-4
1-benzyloxycarbonylpiperidine-4-carboxylic acid

: 1413943-82-4
2-(4-(3-amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)piperidine-1-carbonyl)-3-cyclopropylacrylonitrile

Guidance literature:: Multi-step reaction with 8 steps

1.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 1 h / 20 °C

2.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / -78 - 0 °C

3.1: ISOPROPYLAMIDE / 0.17 h / 250 °C / Microwave irradiation

4.1: trichlorophosphate / N,N-dimethyl-formamide / 0.83 h / 90 °C

5.1: hydrazine hydrate / N,N-dimethyl-formamide / 1.5 h / 110 °C

5.2: 1.5 h / 20 °C

6.1: hydrogenchloride / methanol / 3 h / Reflux

6.2: pH 11

7.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane; N,N-dimethyl-formamide / 0 - 20 °C

8.1: piperidine / methanol / 1.5 h / 20 °C

With piperidine; hydrogenchloride; n-butyllithium; oxalyl dichloride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; hydrazine hydrate; diisopropylamine; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; methanol; hexane; dichloromethane; ISOPROPYLAMIDE; N,N-dimethyl-formamide;

Reference yield:

: 498-94-2
isonipecotic acid

: 1413943-82-4
2-(4-(3-amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)piperidine-1-carbonyl)-3-cyclopropylacrylonitrile

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydroxide / toluene; water / 4 h / 20 °C

2.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 1 h / 20 °C

3.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / -78 - 0 °C

4.1: ISOPROPYLAMIDE / 0.17 h / 250 °C / Microwave irradiation

5.1: trichlorophosphate / N,N-dimethyl-formamide / 0.83 h / 90 °C

6.1: hydrazine hydrate / N,N-dimethyl-formamide / 1.5 h / 110 °C

6.2: 1.5 h / 20 °C

7.1: hydrogenchloride / methanol / 3 h / Reflux

7.2: pH 11

8.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane; N,N-dimethyl-formamide / 0 - 20 °C

9.1: piperidine / methanol / 1.5 h / 20 °C

With piperidine; hydrogenchloride; n-butyllithium; oxalyl dichloride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; hydrazine hydrate; diisopropylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; hexane; dichloromethane; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide; toluene;