Technology Process of (2S,3S)-4-(benzyloxy)-2-(tert-butyldiphenylsiloxy)-3-methylbutyraldehyde
There total 9 articles about (2S,3S)-4-(benzyloxy)-2-(tert-butyldiphenylsiloxy)-3-methylbutyraldehyde which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
4 A molecular sieve; pyridinium chlorochromate;
In
dichloromethane;
at 25 ℃;
for 3h;
DOI:10.1021/jo00209a017
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 98 percent / p-TsOH / Ambient temperature
2: 92 percent / NaH / 1,2-dimethoxy-ethane / 18 h / 65 °C
3: 80 percent / amberlite IR-120HCP / ethane-1,2-diol; 1,2-dimethoxy-ethane / 48 h / 45 °C
4: 84 percent / pyridine / 2 h / Ambient temperature
5: 98 percent / imidazole / dimethylformamide / 48 h / Ambient temperature
6: 98 percent / diisobutylaluminum hydride / CH2Cl2; hexane / 0.5 h / -78 °C
7: 90 percent / pyridinium chlorochromate, 4A molecular sieves / CH2Cl2 / 3 h / 25 °C
With
pyridine; 1H-imidazole; 4 A molecular sieve; amberlite IR-120HCP; sodium hydride; diisobutylaluminium hydride; toluene-4-sulfonic acid; pyridinium chlorochromate;
In
1,2-dimethoxyethane; hexane; dichloromethane; ethylene glycol; N,N-dimethyl-formamide;
DOI:10.1021/jo00209a017
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 100 percent / H2 / 10percent Pd/C / ethanol / 48 h / 25 °C
2: 98 percent / p-TsOH / Ambient temperature
3: 92 percent / NaH / 1,2-dimethoxy-ethane / 18 h / 65 °C
4: 80 percent / amberlite IR-120HCP / ethane-1,2-diol; 1,2-dimethoxy-ethane / 48 h / 45 °C
5: 84 percent / pyridine / 2 h / Ambient temperature
6: 98 percent / imidazole / dimethylformamide / 48 h / Ambient temperature
7: 98 percent / diisobutylaluminum hydride / CH2Cl2; hexane / 0.5 h / -78 °C
8: 90 percent / pyridinium chlorochromate, 4A molecular sieves / CH2Cl2 / 3 h / 25 °C
With
pyridine; 1H-imidazole; 4 A molecular sieve; amberlite IR-120HCP; hydrogen; sodium hydride; diisobutylaluminium hydride; toluene-4-sulfonic acid; pyridinium chlorochromate;
palladium on activated charcoal;
In
1,2-dimethoxyethane; ethanol; hexane; dichloromethane; ethylene glycol; N,N-dimethyl-formamide;
DOI:10.1021/jo00209a017
