1-(3-{3-[4-(2-Chloro-ethyl)-1H-imidazol-2-yl]-propoxy}-benzyl)-piperidine

Base Information

Chemical Name:1-(3-{3-[4-(2-Chloro-ethyl)-1H-imidazol-2-yl]-propoxy}-benzyl)-piperidine
CAS No.:149071-81-8
Molecular Formula:C₂₀H₂₈ClN₃O
Molecular Weight:361.915
Hs Code.:

Synonyms:1-(3-{3-[4-(2-Chloro-ethyl)-1H-imidazol-2-yl]-propoxy}-benzyl)-piperidine

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Chemical Property of 1-(3-{3-[4-(2-Chloro-ethyl)-1H-imidazol-2-yl]-propoxy}-benzyl)-piperidine

Chemical Property:

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Technology Process of 1-(3-{3-[4-(2-Chloro-ethyl)-1H-imidazol-2-yl]-propoxy}-benzyl)-piperidine

There total 3 articles about 1-(3-{3-[4-(2-Chloro-ethyl)-1H-imidazol-2-yl]-propoxy}-benzyl)-piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 149071-68-1
2-{2-[3-(3-Piperidin-1-ylmethyl-phenoxy)-propyl]-1H-imidazol-4-yl}-ethanol

: 149071-81-8
1-(3-{3-[4-(2-Chloro-ethyl)-1H-imidazol-2-yl]-propoxy}-benzyl)-piperidine

Guidance literature:: With thionyl chloride; for 4h; Ambient temperature;
DOI:10.1002/ardp.19933260306

Reference yield:

: 73279-30-8
4-[3-(1-piperidinylmethyl)phenoxy]butanitrile

: 149071-81-8
1-(3-{3-[4-(2-Chloro-ethyl)-1H-imidazol-2-yl]-propoxy}-benzyl)-piperidine

Guidance literature:: Multi-step reaction with 3 steps

1: HCl-gas / CH₂Cl₂ / 48 h / Ambient temperature

2: liq. NH₃ / 1) r.t., overnight, 2) 5 h, 55-60 deg C (20 bar)

3: 73 percent / SOCl₂ / 4 h / Ambient temperature

With hydrogenchloride; thionyl chloride; ammonia; In dichloromethane;
DOI:10.1002/ardp.19933260306

Reference yield:

: 4-(3-Piperidin-1-ylmethyl-phenoxy)-butyrimidic acid methyl ester; hydrochloride

: 149071-81-8
1-(3-{3-[4-(2-Chloro-ethyl)-1H-imidazol-2-yl]-propoxy}-benzyl)-piperidine

Guidance literature:: Multi-step reaction with 2 steps

1: liq. NH₃ / 1) r.t., overnight, 2) 5 h, 55-60 deg C (20 bar)

2: 73 percent / SOCl₂ / 4 h / Ambient temperature

With thionyl chloride; ammonia;
DOI:10.1002/ardp.19933260306