7-[(4-ethylpiperazin-1-yl)carbonyl]-2-(4-nitrophenyl)imidazo[2,1-b][1,3]benzothiazole

Base Information

• Chemical Name: 7-[(4-ethylpiperazin-1-yl)carbonyl]-2-(4-nitrophenyl)imidazo[2,1-b][1,3]benzothiazole
• CAS No.: 1191251-76-9
• Molecular Formula: C₂₂H₂₁N₅O₃S
• Molecular Weight: 435.506

Synonyms:7-[(4-ethylpiperazin-1-yl)carbonyl]-2-(4-nitrophenyl)imidazo[2,1-b][1,3]benzothiazole

Chemical Property of 7-[(4-ethylpiperazin-1-yl)carbonyl]-2-(4-nitrophenyl)imidazo[2,1-b][1,3]benzothiazole

Chemical Property:

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Technology Process of 7-[(4-ethylpiperazin-1-yl)carbonyl]-2-(4-nitrophenyl)imidazo[2,1-b][1,3]benzothiazole

There total 1 articles about 7-[(4-ethylpiperazin-1-yl)carbonyl]-2-(4-nitrophenyl)imidazo[2,1-b][1,3]benzothiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

4-ethylpiperazine (5308-25-8) + 2-(4-nitrophenyl)imidazo[2,1-b][1,3]benzothiazol-7-carboxylic acid (1191251-75-8) → 7-[(4-ethylpiperazin-1-yl)carbonyl]-2-(4-nitrophenyl)imidazo[2,1-b][1,3]benzothiazole (1191251-76-9)

Guidance literature:

2-(4-nitrophenyl)imidazo[2,1-b][1,3]benzothiazol-7-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 1h; Inert atmosphere;

4-ethylpiperazine; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

DOI:10.1021/jm9007533

Reference yield: 56.0%

7-[(4-ethylpiperazin-1-yl)carbonyl]-2-(4-nitrophenyl)imidazo[2,1-b][1,3]benzothiazole (1191251-76-9) → 4-{7-[4-(ethylpiperazin-1-yl)carbonyl]imidazo[2,1-b][1,3]benzothiazol-2-yl}aniline (1191251-77-0)

Guidance literature:

With tin(II) chloride hydrate; In ethanol; at 90 ℃; Inert atmosphere;

DOI:10.1021/jm9007533

upstream raw materials:

4-ethylpiperazine

2-(4-nitrophenyl)imidazo[2,1-b][1,3]benzothiazol-7-carboxylic acid

Downstream raw materials:

4-{7-[4-(ethylpiperazin-1-yl)carbonyl]imidazo[2,1-b][1,3]benzothiazol-2-yl}aniline

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