methyl 3-((S)-3-((S)-2(benzyloxycarbonyl)pyrrolidin-1-yl)-2-(1,3-dioxoisoindolin-2-yl)-3-oxopropyl)-1H-indole-6-carboxylate

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Chemical Name:methyl 3-((S)-3-((S)-2(benzyloxycarbonyl)pyrrolidin-1-yl)-2-(1,3-dioxoisoindolin-2-yl)-3-oxopropyl)-1H-indole-6-carboxylate
CAS No.:1206486-12-5
Molecular Formula:C₃₃H₂₉N₃O₇
Molecular Weight:579.609
Hs Code.:

Synonyms:methyl 3-((S)-3-((S)-2(benzyloxycarbonyl)pyrrolidin-1-yl)-2-(1,3-dioxoisoindolin-2-yl)-3-oxopropyl)-1H-indole-6-carboxylate

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Chemical Property of methyl 3-((S)-3-((S)-2(benzyloxycarbonyl)pyrrolidin-1-yl)-2-(1,3-dioxoisoindolin-2-yl)-3-oxopropyl)-1H-indole-6-carboxylate

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Technology Process of methyl 3-((S)-3-((S)-2(benzyloxycarbonyl)pyrrolidin-1-yl)-2-(1,3-dioxoisoindolin-2-yl)-3-oxopropyl)-1H-indole-6-carboxylate

There total 1 articles about methyl 3-((S)-3-((S)-2(benzyloxycarbonyl)pyrrolidin-1-yl)-2-(1,3-dioxoisoindolin-2-yl)-3-oxopropyl)-1H-indole-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1206486-30-7
C₂₁H₁₆N₂O₆

: 41324-66-7
H-Pro-OBzl

: 1206486-12-5
methyl 3-((S)-3-((S)-2(benzyloxycarbonyl)pyrrolidin-1-yl)-2-(1,3-dioxoisoindolin-2-yl)-3-oxopropyl)-1H-indole-6-carboxylate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 ℃; for 8h;
DOI:10.1021/ja909870g

Reference yield: 92.0%

: 883556-49-8
N^α-benzyloxycarbonyl-N^G-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-L-arginyl-L-histidine tert-butyl ester

: 1206486-12-5
methyl 3-((S)-3-((S)-2(benzyloxycarbonyl)pyrrolidin-1-yl)-2-(1,3-dioxoisoindolin-2-yl)-3-oxopropyl)-1H-indole-6-carboxylate

: 1206486-13-6
C₇₀H₇₈N₁₀O₁₅S

Guidance literature:: methyl 3-((S)-3-((S)-2(benzyloxycarbonyl)pyrrolidin-1-yl)-2-(1,3-dioxoisoindolin-2-yl)-3-oxopropyl)-1H-indole-6-carboxylate; With N,N'-dimethylpiperazine; N-chloro-succinimide; In dichloromethane; at 20 ℃; for 5h;

N^α-benzyloxycarbonyl-N^G-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-L-arginyl-L-histidine tert-butyl ester; In dichloromethane; at 20 ℃; for 10h;
DOI:10.1021/ja909870g