(2R,3R,8R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-3-hydroxy-8-methyl-10-oxo-undecanoic acid

Base Information

Chemical Name:(2R,3R,8R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-3-hydroxy-8-methyl-10-oxo-undecanoic acid
CAS No.:123487-30-9
Molecular Formula:C₂₉H₄₂O₅Si
Molecular Weight:498.735
Hs Code.:

Synonyms:(2R,3R,8R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-3-hydroxy-8-methyl-10-oxo-undecanoic acid

Suppliers and Price of (2R,3R,8R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-3-hydroxy-8-methyl-10-oxo-undecanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,3R,8R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-3-hydroxy-8-methyl-10-oxo-undecanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,3R,8R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-3-hydroxy-8-methyl-10-oxo-undecanoic acid

There total 20 articles about (2R,3R,8R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-3-hydroxy-8-methyl-10-oxo-undecanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 123487-23-0
(2R,3R,8R)-methyl 2-<((tert-butyldiphenylsilyl)oxy)methyl>-3-hydroxy-8-methyl-10-oxoundecanoate

: 123487-30-9
(2R,3R,8R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-3-hydroxy-8-methyl-10-oxo-undecanoic acid

Guidance literature:: With sodium hydroxide; In isopropyl alcohol; at 60 ℃; for 0.5h;
DOI:10.1021/jo00285a017

Reference yield:

: 123487-17-2
(6R)-6-methyl-8,8-(ethylenedioxy)nonanal

: 123487-30-9
(2R,3R,8R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-3-hydroxy-8-methyl-10-oxo-undecanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 1) lithium bis(trimethylsilyl)amide / 1) THF, -10 deg C, 45 min, 2) THF, -100 deg C, 1.25 h

2: 90 percent / potassium carbonate / 3 h / Ambient temperature

3: 1) lithium diisopropylamide / 1) THF, -78 deg C, 1.0 h, 2a) -78 deg C up to -25 deg C, 4.0 h, 2b) -25 deg C, 12.0 h

4: 100 percent / hydrogen / 10percent Pd-C / ethyl acetate / 1 h / 2585.7 Torr

5: 78 percent / imidazole / dimethylformamide / 3 h

6: 0.3N aq. sodium hydroxide / propan-2-ol / 0.5 h / 60 °C

With 1H-imidazole; sodium hydroxide; hydrogen; potassium carbonate; lithium hexamethyldisilazane; lithium diisopropyl amide; palladium on activated charcoal; In ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/jo00058a057

Reference yield:

: 146500-58-5
(3R,8R)-methyl 3-hydroxy-8-methyl-10,10-(ethylenedioxy)undecanoate

: 123487-30-9
(2R,3R,8R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-3-hydroxy-8-methyl-10-oxo-undecanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1) lithium diisopropylamide / 1) THF, -78 deg C, 1.0 h, 2a) -78 deg C up to -25 deg C, 4.0 h, 2b) -25 deg C, 12.0 h

2: 100 percent / hydrogen / 10percent Pd-C / ethyl acetate / 1 h / 2585.7 Torr

3: 78 percent / imidazole / dimethylformamide / 3 h

4: 0.3N aq. sodium hydroxide / propan-2-ol / 0.5 h / 60 °C

With 1H-imidazole; sodium hydroxide; hydrogen; lithium diisopropyl amide; palladium on activated charcoal; In ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/jo00058a057