7-Benzyl-8-cyclopentylmethyl-2-((1R,2R)-2-hydroxy-cyclopentylamino)-1-methyl-1,7-dihydro-purin-6-one

Base Information

• Chemical Name: 7-Benzyl-8-cyclopentylmethyl-2-((1R,2R)-2-hydroxy-cyclopentylamino)-1-methyl-1,7-dihydro-purin-6-one
• CAS No.: 1026282-06-3
• Molecular Formula: C₂₄H₃₁N₅O₂
• Molecular Weight: 421.542

Synonyms:7-Benzyl-8-cyclopentylmethyl-2-((1R,2R)-2-hydroxy-cyclopentylamino)-1-methyl-1,7-dihydro-purin-6-one

Chemical Property of 7-Benzyl-8-cyclopentylmethyl-2-((1R,2R)-2-hydroxy-cyclopentylamino)-1-methyl-1,7-dihydro-purin-6-one

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 7-Benzyl-8-cyclopentylmethyl-2-((1R,2R)-2-hydroxy-cyclopentylamino)-1-methyl-1,7-dihydro-purin-6-one

There total 4 articles about 7-Benzyl-8-cyclopentylmethyl-2-((1R,2R)-2-hydroxy-cyclopentylamino)-1-methyl-1,7-dihydro-purin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1R,2R)-2-aminocyclopentanol (930-45-0,33092-86-3,33092-90-9,57070-95-8,59260-76-3,68327-03-7,89381-13-5,135969-63-0) + 7-Benzyl-2-chloro-8-cyclopentylmethyl-1-methyl-1,7-dihydro-purin-6-one (1026592-81-3) → 7-Benzyl-8-cyclopentylmethyl-2-((1R,2R)-2-hydroxy-cyclopentylamino)-1-methyl-1,7-dihydro-purin-6-one (1026282-06-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In various solvent(s); at 130 ℃;

DOI:10.1021/jm9608467

Reference yield:

2-cyclopentylacetic acid (1123-00-8) → 7-Benzyl-8-cyclopentylmethyl-2-((1R,2R)-2-hydroxy-cyclopentylamino)-1-methyl-1,7-dihydro-purin-6-one (1026282-06-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 1-<3-(diethylamino)propyl>-3-ethylcarbodiimide, 4-(N,N-dimethylamino)pyridine / dimethylformamide / Ambient temperature

2: POCl₃ / 7 h / Heating

3: diisopropylethylamine / various solvent(s) / 130 °C

With dmap; N-ethyl-N'-(3-diethylaminopropyl)-carbodiimide; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In N,N-dimethyl-formamide;

DOI:10.1021/jm9608467

Reference yield:

6-amino-5-(benzylamino)-3-methylpyrimidine-2,4(1H,3H)-dione (2034-31-3) → 7-Benzyl-8-cyclopentylmethyl-2-((1R,2R)-2-hydroxy-cyclopentylamino)-1-methyl-1,7-dihydro-purin-6-one (1026282-06-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 1-<3-(diethylamino)propyl>-3-ethylcarbodiimide, 4-(N,N-dimethylamino)pyridine / dimethylformamide / Ambient temperature

2: POCl₃ / 7 h / Heating

3: diisopropylethylamine / various solvent(s) / 130 °C

With dmap; N-ethyl-N'-(3-diethylaminopropyl)-carbodiimide; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In N,N-dimethyl-formamide;

DOI:10.1021/jm9608467

upstream raw materials:

(1R,2R)-2-aminocyclopentanol

7-Benzyl-2-chloro-8-cyclopentylmethyl-1-methyl-1,7-dihydro-purin-6-one

2-cyclopentylacetic acid

6-amino-5-(benzylamino)-3-methylpyrimidine-2,4(1H,3H)-dione

Downstream raw materials:

(6aR,9aS)-2-(cyclopentylmethyl)-5,6a,7,8,9,9a-hexahydro-5-methyl-3-(phenylmethyl)cyclopent[4,5]imidazo[2,1-b]purin-4(3H)-one

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