(±)-1-benzyl-4-(3-hydroxyphenyl)-5-phenyl-3,4-dihydropyrimidine-2(1H)-one

Base Information

Chemical Name:(±)-1-benzyl-4-(3-hydroxyphenyl)-5-phenyl-3,4-dihydropyrimidine-2(1H)-one
CAS No.:1609637-85-5
Molecular Formula:C₂₃H₂₀N₂O₂
Molecular Weight:356.424
Hs Code.:

Synonyms:(±)-1-benzyl-4-(3-hydroxyphenyl)-5-phenyl-3,4-dihydropyrimidine-2(1H)-one

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Chemical Property of (±)-1-benzyl-4-(3-hydroxyphenyl)-5-phenyl-3,4-dihydropyrimidine-2(1H)-one

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Technology Process of (±)-1-benzyl-4-(3-hydroxyphenyl)-5-phenyl-3,4-dihydropyrimidine-2(1H)-one

There total 4 articles about (±)-1-benzyl-4-(3-hydroxyphenyl)-5-phenyl-3,4-dihydropyrimidine-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 122476-84-0
1-benzyl-5-phenylpyrimidin-2(1H)-one

: 3-(t-butyldimethylsilanyloxy)phenyllithium

: 1609637-85-5
(±)-1-benzyl-4-(3-hydroxyphenyl)-5-phenyl-3,4-dihydropyrimidine-2(1H)-one

Guidance literature:: 1-benzyl-5-phenylpyrimidin-2(1H)-one; 3-(t-butyldimethylsilanyloxy)phenyllithium; In tetrahydrofuran; at 0 ℃; for 0.5h; Schlenk technique; Inert atmosphere;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1.25h; Schlenk technique; Inert atmosphere;

With hydrogenchloride; silica gel; In tetrahydrofuran; water; ethyl acetate; at 20 ℃; for 20h; Schlenk technique; Inert atmosphere;
DOI:10.1039/c4ob00094c

Reference yield:

: 103594-68-9
1-benzyl-5-bromopyrimidin-2(1H)-one

: 1609637-85-5
(±)-1-benzyl-4-(3-hydroxyphenyl)-5-phenyl-3,4-dihydropyrimidine-2(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene; ethanol / 20 h / 80 °C / Schlenk technique; Inert atmosphere

2.1: tetrahydrofuran / 0.5 h / 0 °C / Schlenk technique; Inert atmosphere

2.2: 1.25 h / 20 °C / Schlenk technique; Inert atmosphere

2.3: 20 h / 20 °C / Schlenk technique; Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; ethanol; water; toluene; 1.1: |Suzuki-Miyaura Coupling;
DOI:10.1039/c4ob00094c

Reference yield:

: 65423-56-5
1-bromo-3-[(tert-butyldimethylsilyl)oxy]benzene

: 1609637-85-5
(±)-1-benzyl-4-(3-hydroxyphenyl)-5-phenyl-3,4-dihydropyrimidine-2(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: tert.-butyl lithium / diethyl ether; pentane / 1.5 h / -80 °C / Schlenk technique; Inert atmosphere

2.1: tetrahydrofuran / 0.5 h / 0 °C / Schlenk technique; Inert atmosphere

2.2: 1.25 h / 20 °C / Schlenk technique; Inert atmosphere

2.3: 20 h / 20 °C / Schlenk technique; Inert atmosphere

With tert.-butyl lithium; In tetrahydrofuran; diethyl ether; pentane;
DOI:10.1039/c4ob00094c