2-[6-(4-methoxybenzylamino)purin-9-yl]-5-(1H-tetrazol-5-yl)tetrahydrofuran-3,4-diol

Base Information

Chemical Name:2-[6-(4-methoxybenzylamino)purin-9-yl]-5-(1H-tetrazol-5-yl)tetrahydrofuran-3,4-diol
CAS No.:1325711-75-8
Molecular Formula:C₁₈H₁₉N₉O₄
Molecular Weight:425.407
Hs Code.:

Synonyms:2-[6-(4-methoxybenzylamino)purin-9-yl]-5-(1H-tetrazol-5-yl)tetrahydrofuran-3,4-diol

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Chemical Property of 2-[6-(4-methoxybenzylamino)purin-9-yl]-5-(1H-tetrazol-5-yl)tetrahydrofuran-3,4-diol

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Technology Process of 2-[6-(4-methoxybenzylamino)purin-9-yl]-5-(1H-tetrazol-5-yl)tetrahydrofuran-3,4-diol

There total 7 articles about 2-[6-(4-methoxybenzylamino)purin-9-yl]-5-(1H-tetrazol-5-yl)tetrahydrofuran-3,4-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1325711-88-3
C₂₁H₂₃N₉O₄

: 1325711-75-8
2-[6-(4-methoxybenzylamino)purin-9-yl]-5-(1H-tetrazol-5-yl)tetrahydrofuran-3,4-diol

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; for 14h;
DOI:10.1002/cmdc.201100126

Reference yield:

: 2004-06-0
6-Chloropurine riboside

: 1325711-75-8
2-[6-(4-methoxybenzylamino)purin-9-yl]-5-(1H-tetrazol-5-yl)tetrahydrofuran-3,4-diol

Guidance literature:: Multi-step reaction with 7 steps

1: toluene-4-sulfonic acid / acetone / 2 h / 20 °C

2: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene / water; acetonitrile / 4 h / 40 °C / Inert atmosphere

3: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; ammonium chloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 14 h / 50 °C

4: oxalyl dichloride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / -78 °C

5: N-ethyl-N,N-diisopropylamine / propan-1-ol / 4 h / 70 °C

6: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 10 h / 0 - 90 °C

7: hydrogenchloride / tetrahydrofuran; water / 14 h / 20 °C

With hydrogenchloride; sodium azide; oxalyl dichloride; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; ammonium chloride; benzotriazol-1-ol; toluene-4-sulfonic acid; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; propan-1-ol; dichloromethane; water; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1002/cmdc.201100126

Reference yield:

: 1325711-76-9
C₁₃H₁₂ClN₅O₃

: 1325711-75-8
2-[6-(4-methoxybenzylamino)purin-9-yl]-5-(1H-tetrazol-5-yl)tetrahydrofuran-3,4-diol

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / propan-1-ol / 4 h / 70 °C

2: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 10 h / 0 - 90 °C

3: hydrogenchloride / tetrahydrofuran; water / 14 h / 20 °C

With hydrogenchloride; sodium azide; ammonium chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; propan-1-ol; water; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201100126