ethyl 6-(4-hydroxyphenyl)-2-oxo-4-(thiophen-2-yl)cyclohex-3-enecarboxylate

Base Information

• Chemical Name: ethyl 6-(4-hydroxyphenyl)-2-oxo-4-(thiophen-2-yl)cyclohex-3-enecarboxylate
• CAS No.: 1268267-52-2
• Molecular Formula: C₁₉H₁₈O₄S
• Molecular Weight: 342.416
• Mol file: 1268267-52-2.mol

Synonyms:ethyl 6-(4-hydroxyphenyl)-2-oxo-4-(thiophen-2-yl)cyclohex-3-enecarboxylate

Chemical Property of ethyl 6-(4-hydroxyphenyl)-2-oxo-4-(thiophen-2-yl)cyclohex-3-enecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 6-(4-hydroxyphenyl)-2-oxo-4-(thiophen-2-yl)cyclohex-3-enecarboxylate

There total 3 articles about ethyl 6-(4-hydroxyphenyl)-2-oxo-4-(thiophen-2-yl)cyclohex-3-enecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-(4-hydroxyphenyl)-1-(thiophene-2-yl)prop-2-en-1-one (19143-12-5) + ethyl acetoacetate (141-97-9) → ethyl 6-(4-hydroxyphenyl)-2-oxo-4-(thiophen-2-yl)cyclohex-3-enecarboxylate (1268267-52-2)

Guidance literature:

With potassium carbonate; for 0.166667h; Milling;

DOI:10.1007/s11164-015-2379-5

Reference yield: 85.0%

ethyl acetoacetate (141-97-9) + (E)-3-(4-hydroxyphenyl)-1-(thiophen-2-yl)prop-2-en-1-one → ethyl 6-(4-hydroxyphenyl)-2-oxo-4-(thiophen-2-yl)cyclohex-3-enecarboxylate (1268267-52-2)

Guidance literature:

With piperidine; for 0.0666667h; Microwave irradiation; neat (no solvent, solid phase);

Reference yield:

2-Acetylthiophene (88-15-3,97511-16-5) + 4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → ethyl 6-(4-hydroxyphenyl)-2-oxo-4-(thiophen-2-yl)cyclohex-3-enecarboxylate (1268267-52-2)

Guidance literature:

Multi-step reaction with 2 steps

1: basic alumina / Microwave irradiation

2: piperidine / 0.07 h / Microwave irradiation; neat (no solvent, solid phase)

With piperidine; 2: Michael condensation;

upstream raw materials:

2-Acetylthiophene

4-hydroxy-benzaldehyde

ethyl acetoacetate

3-(4-hydroxyphenyl)-1-(thiophene-2-yl)prop-2-en-1-one