tert-butyl(3aR,4R,6aS)-4-{{[(1R)-1-biphenyl-4-yl-2-methoxy-2-oxoethyl]amino}methyl}-2,2-dimethyltetrahydro-5H-[1,3]dioxolo[4,5-c]pyrrole-5-carboxylate

Base Information

• Chemical Name: tert-butyl(3aR,4R,6aS)-4-{{[(1R)-1-biphenyl-4-yl-2-methoxy-2-oxoethyl]amino}methyl}-2,2-dimethyltetrahydro-5H-[1,3]dioxolo[4,5-c]pyrrole-5-carboxylate
• CAS No.: 1159576-06-3
• Molecular Formula: C₂₈H₃₆N₂O₆
• Molecular Weight: 496.604

Synonyms:tert-butyl(3aR,4R,6aS)-4-{{[(1R)-1-biphenyl-4-yl-2-methoxy-2-oxoethyl]amino}methyl}-2,2-dimethyltetrahydro-5H-[1,3]dioxolo[4,5-c]pyrrole-5-carboxylate

Chemical Property of tert-butyl(3aR,4R,6aS)-4-{{[(1R)-1-biphenyl-4-yl-2-methoxy-2-oxoethyl]amino}methyl}-2,2-dimethyltetrahydro-5H-[1,3]dioxolo[4,5-c]pyrrole-5-carboxylate

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Technology Process of tert-butyl(3aR,4R,6aS)-4-{{[(1R)-1-biphenyl-4-yl-2-methoxy-2-oxoethyl]amino}methyl}-2,2-dimethyltetrahydro-5H-[1,3]dioxolo[4,5-c]pyrrole-5-carboxylate

There total 1 articles about tert-butyl(3aR,4R,6aS)-4-{{[(1R)-1-biphenyl-4-yl-2-methoxy-2-oxoethyl]amino}methyl}-2,2-dimethyltetrahydro-5H-[1,3]dioxolo[4,5-c]pyrrole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

methyl 4-phenyl-D-phenylglycinate + (3aR,4S,6aS)-tert-butyl 4-formyl-2,2-dimethyldihydro-3aH-[1,3]dioxolo[4,5-c]pyrrole-5(4H)-carboxylate (117781-13-2) → tert-butyl(3aR,4R,6aS)-4-{{[(1R)-1-biphenyl-4-yl-2-methoxy-2-oxoethyl]amino}methyl}-2,2-dimethyltetrahydro-5H-[1,3]dioxolo[4,5-c]pyrrole-5-carboxylate (1159576-06-3)

Guidance literature:

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2010.03.009

Reference yield: 85.0%

tert-butyl(3aR,4R,6aS)-4-{{[(1R)-1-biphenyl-4-yl-2-methoxy-2-oxoethyl]amino}methyl}-2,2-dimethyltetrahydro-5H-[1,3]dioxolo[4,5-c]pyrrole-5-carboxylate (1159576-06-3) → C27H36N2O5 (1159576-08-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 3h;

upstream raw materials:

(3aR,4S,6aS)-tert-butyl 4-formyl-2,2-dimethyldihydro-3aH-[1,3]dioxolo[4,5-c]pyrrole-5(4H)-carboxylate

Downstream raw materials:

C₂₇H₃₆N₂O₅

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