1H-Indene-2-carboxylic acid, 2-aMino-2,3-dihydro-, phenylMethyl ester, hydrochloride

Base Information

• Chemical Name: 1H-Indene-2-carboxylic acid, 2-aMino-2,3-dihydro-, phenylMethyl ester, hydrochloride
• CAS No.: 132970-26-4
• Molecular Formula: C₁₇H₁₇NO₂*ClH
• Molecular Weight: 303.788
• Mol file: 132970-26-4.mol

Synonyms:2-Indan amino acid benzyl ester hydrochloride

Chemical Property of 1H-Indene-2-carboxylic acid, 2-aMino-2,3-dihydro-, phenylMethyl ester, hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1H-Indene-2-carboxylic acid, 2-aMino-2,3-dihydro-, phenylMethyl ester, hydrochloride

There total 3 articles about 1H-Indene-2-carboxylic acid, 2-aMino-2,3-dihydro-, phenylMethyl ester, hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-tert-Butoxycarbonylamino-indan-2-carboxylic acid benzyl ester (137381-04-5) → 2-Indan amino acid benzyl ester hydrochloride (132970-26-4)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; for 2h; Yield given; Ambient temperature;

DOI:10.1021/jm00124a028

Reference yield:

2-((tert-butoxycarbonyl)amino)-2,3-dihydro-1H-indene-2-carboxylic acid (71066-00-7) → 2-Indan amino acid benzyl ester hydrochloride (132970-26-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) tetramethylammonium hydroxide / 1) MeOH, 2) Me₂SO, 60 deg C, 4 h to 4 days

2: 4 N HCl / dioxane / 2 h / Ambient temperature

With hydrogenchloride; tetramethyl ammoniumhydroxide; In 1,4-dioxane;

DOI:10.1021/jm00124a028

Reference yield:

benzyl chloride (100-44-7) → 2-Indan amino acid benzyl ester hydrochloride (132970-26-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) tetramethylammonium hydroxide / 1) MeOH, 2) Me₂SO, 60 deg C, 4 h to 4 days

2: 4 N HCl / dioxane / 2 h / Ambient temperature

With hydrogenchloride; tetramethyl ammoniumhydroxide; In 1,4-dioxane;

DOI:10.1021/jm00124a028

upstream raw materials:

2-tert-Butoxycarbonylamino-indan-2-carboxylic acid benzyl ester

2-((tert-butoxycarbonyl)amino)-2,3-dihydro-1H-indene-2-carboxylic acid

benzyl chloride

Refernces