{tert-butyl-[3-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzoyl]-amino}-acetic acid

Base Information

Chemical Name:{tert-butyl-[3-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzoyl]-amino}-acetic acid
CAS No.:1306754-17-5
Molecular Formula:C₂₇H₂₇F₂NO₅
Molecular Weight:483.512
Hs Code.:

Synonyms:{tert-butyl-[3-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzoyl]-amino}-acetic acid

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Chemical Property of {tert-butyl-[3-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzoyl]-amino}-acetic acid

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Technology Process of {tert-butyl-[3-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzoyl]-amino}-acetic acid

There total 2 articles about {tert-butyl-[3-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzoyl]-amino}-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1306754-48-2
{[3-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzoyl]-tert-butyl-amino}-acetic acid methyl ester

: 1306754-17-5
{tert-butyl-[3-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzoyl]-amino}-acetic acid

Guidance literature:: {[3-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzoyl]-tert-butyl-amino}-acetic acid methyl ester; With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 12h;

With hydrogenchloride; In water; pH=1; Cooling with ice;

Reference yield:

: 53386-65-5
N-(t-butyl)glycine methyl ester

: 1306754-43-7
3-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzoyl chloride

: 1306754-17-5
{tert-butyl-[3-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzoyl]-amino}-acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / tetrahydrofuran / 0 - 20 °C

2.1: water; lithium hydroxide / tetrahydrofuran / 12 h / 20 °C

2.2: pH 1 / Cooling with ice

With water; triethylamine; lithium hydroxide; In tetrahydrofuran;