Technology Process of ((3R,7R,11R)-3-(benzyloxy)-3,7,11,15-tetramethylhexadec-1-ynyl)tributylstannane
There total 6 articles about ((3R,7R,11R)-3-(benzyloxy)-3,7,11,15-tetramethylhexadec-1-ynyl)tributylstannane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-benzoxy-(3R,7R,11R)-3,7,11,15-tetramethylhexadec-1-yne;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 - 0 ℃;
for 0.333333h;
tributyltin chloride;
In
tetrahydrofuran; hexane;
at 0 - 20 ℃;
for 4h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triethylamine / dmap / dichloromethane / 20 °C
2.1: lithium chloride / N,N-dimethyl-formamide / 1 h / 60 °C
3.1: n-butyllithium / hexane; tetrahydrofuran / 0.33 h / -20 °C / Inert atmosphere
3.2: -20 °C / Inert atmosphere
4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C
4.2: 1 h / 0 - 20 °C
5.1: n-butyllithium / hexane; tetrahydrofuran / 0.33 h / -78 - 0 °C
5.2: 4 h / 0 - 20 °C
With
n-butyllithium; sodium hydride; triethylamine; lithium chloride;
dmap;
In
tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; mineral oil;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: titanium(IV) isopropylate; tert.-butylhydroperoxide; diethyl (2S,3S)-tartrate / dichloromethane; nonane / 3 h / -20 °C / Molecular sieve; Inert atmosphere
2.1: triethylamine / dmap / dichloromethane / 20 °C
3.1: lithium chloride / N,N-dimethyl-formamide / 1 h / 60 °C
4.1: n-butyllithium / hexane; tetrahydrofuran / 0.33 h / -20 °C / Inert atmosphere
4.2: -20 °C / Inert atmosphere
5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C
5.2: 1 h / 0 - 20 °C
6.1: n-butyllithium / hexane; tetrahydrofuran / 0.33 h / -78 - 0 °C
6.2: 4 h / 0 - 20 °C
With
titanium(IV) isopropylate; tert.-butylhydroperoxide; n-butyllithium; diethyl (2S,3S)-tartrate; sodium hydride; triethylamine; lithium chloride;
dmap;
In
tetrahydrofuran; nonane; hexane; dichloromethane; N,N-dimethyl-formamide; mineral oil;
