1H-Pyrrole-2-carboxaldehyde,3,5-dimethyl-4-nitro-(9CI)

Base Information

• Chemical Name: 1H-Pyrrole-2-carboxaldehyde,3,5-dimethyl-4-nitro-(9CI)
• CAS No.: 40236-20-2
• Molecular Formula: C7H8 N2 O3
• Molecular Weight: 168.152
• Mol file: 40236-20-2.mol

Synonyms:1H-Pyrrole-2-carboxaldehyde,3,5-dimethyl-4-nitro-(9CI)

Chemical Property of 1H-Pyrrole-2-carboxaldehyde,3,5-dimethyl-4-nitro-(9CI)

Chemical Property:

• Melting Point: 220-229 °C (decomp)
• Boiling Point: 307.5±42.0 °C(Predicted)
• PKA: 13.19±0.50(Predicted)
• PSA: 78.68000
• Density: 1.358±0.06 g/cm3(Predicted)
• LogP: 1.87540
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

3,5-Dimethyl-4-nitro-1H-pyrrole-2-carbaldehyde 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1H-Pyrrole-2-carboxaldehyde,3,5-dimethyl-4-nitro-(9CI)

There total 1 articles about 1H-Pyrrole-2-carboxaldehyde,3,5-dimethyl-4-nitro-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

5-(benzoylamino)-1,2,4-trimethyl-3-nitropyridinium methyl sulfate → 3,5-dimethyl-4-nitro-1H-pyrrole-2-carbaldehyde (40236-20-2) + N-[2-methyl-4-(methylamino)-3-nitrophenyl]benzamide

Guidance literature:

With methylamine; In ethanol; N,N-dimethyl-formamide; at 20 ℃; for 72h;

DOI:10.3998/ark.5550190.p009.810

Reference yield: 96.0%

3,5-dimethyl-4-nitro-1H-pyrrole-2-carbaldehyde (40236-20-2) + (R)-N-(1-(4-chlorophenyl)ethyl)-2-oxoindoline-5-carboxamide → (R,Z)-N-(1-(4-chlorophenyl)ethyl)-3-((3,5-dimethyl-4-nitro-1H-pyrrol-2-yl)methylene)-2-oxoindoline-5-carboxamide

Guidance literature:

With piperidine; In ethanol; at 95 ℃; for 4h; Sealed tube;

DOI:10.1021/acs.jmedchem.0c01522

Reference yield: 64.8%

3,5-dimethyl-4-nitro-1H-pyrrole-2-carbaldehyde (40236-20-2) + (R)-N-(2-methyl-1-phenylpropyl)-2-oxoindoline-5-carboxamide → (R,Z)-3-((3,5-dimethyl-4-nitro-1H-pyrrol-2-yl)methylene)-N-(2-methyl-1-phenylpropyl)-2-oxoindoline-5-carboxamide

Guidance literature:

With piperidine; In ethanol; at 95 ℃; for 4h; Sealed tube;

DOI:10.1021/acs.jmedchem.0c01522

Refernces