amide of N-t-butyloxycarbonyl-β-alanyl-O-benzyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-leucine

Base Information

Chemical Name:amide of N-t-butyloxycarbonyl-β-alanyl-O-benzyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-leucine
CAS No.:81638-90-6
Molecular Formula:C₄₃H₅₇N₇O₉
Molecular Weight:815.967
Hs Code.:

Synonyms:amide of N-t-butyloxycarbonyl-β-alanyl-O-benzyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-leucine

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Chemical Property of amide of N-t-butyloxycarbonyl-β-alanyl-O-benzyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-leucine

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Technology Process of amide of N-t-butyloxycarbonyl-β-alanyl-O-benzyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-leucine

There total 12 articles about amide of N-t-butyloxycarbonyl-β-alanyl-O-benzyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-leucine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 687-51-4,13079-20-4,13366-40-0,15893-47-7
H-L-Leu-NH₂

: 81638-90-6
amide of N-t-butyloxycarbonyl-β-alanyl-O-benzyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-leucine

Guidance literature:: Multi-step reaction with 7 steps

1: 90 percent / AcOH / tetrahydrofuran / 48 h / 30 °C

2: 100 percent / 2 M HCl / acetic acid / 0.75 h

3: 1.) NH₃, 2.) AcOH / 1.) THF, CHCl₃, 2.) THF, 24 h

4: 98 percent / 2 M HCl / acetic acid / 0.75 h

5: 1.) NH₃, 2.) AcOH / 1.) DMF, CHCl₃, 2.) THF, 24 h

6: 100 percent / 2 M HCl / acetic acid / 0.75 h

7: 1.) NH₃, 2.) AcOH / 1.) DMF, CHCl₃, 2.) THF, 24 h

With hydrogenchloride; ammonia; acetic acid; In tetrahydrofuran; acetic acid;

Reference yield:

: 3303-84-2
3-(tert-butyloxycarbonylamino)propionic acid

: 81638-90-6
amide of N-t-butyloxycarbonyl-β-alanyl-O-benzyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-leucine

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / N,N'-dicyclohexylcarbodiimide (DCCI) / tetrahydrofuran / Ambient temperature

2: 1.) NH₃, 2.) AcOH / 1.) DMF, CHCl₃, 2.) THF, 24 h

With ammonia; acetic acid; dicyclohexyl-carbodiimide; In tetrahydrofuran;

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 81638-90-6
amide of N-t-butyloxycarbonyl-β-alanyl-O-benzyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-leucine

Guidance literature:: Multi-step reaction with 8 steps

1: 90 percent / N,N'-dicyclohexylcarbodiimide (DCCI) / tetrahydrofuran / Ambient temperature

2: 90 percent / AcOH / tetrahydrofuran / 48 h / 30 °C

3: 100 percent / 2 M HCl / acetic acid / 0.75 h

4: 1.) NH₃, 2.) AcOH / 1.) THF, CHCl₃, 2.) THF, 24 h

5: 98 percent / 2 M HCl / acetic acid / 0.75 h

6: 1.) NH₃, 2.) AcOH / 1.) DMF, CHCl₃, 2.) THF, 24 h

7: 100 percent / 2 M HCl / acetic acid / 0.75 h

8: 1.) NH₃, 2.) AcOH / 1.) DMF, CHCl₃, 2.) THF, 24 h

With hydrogenchloride; ammonia; acetic acid; dicyclohexyl-carbodiimide; In tetrahydrofuran; acetic acid;