α-[[(1,1-DiMethylethoxy)carbonyl]aMino]-2-fluoro-4-hydroxybenzeneacetic Acid

Base Information

• Chemical Name: α-[[(1,1-DiMethylethoxy)carbonyl]aMino]-2-fluoro-4-hydroxybenzeneacetic Acid
• CAS No.: 1131872-19-9
• Molecular Formula: C₁₃H₁₆FNO₅
• Molecular Weight: 285.272
• Mol file: 1131872-19-9.mol

Synonyms:tert-butoxycarbonylamino-(2-fluoro-4-hydroxyphenyl)acetic acid

Chemical Property of α-[[(1,1-DiMethylethoxy)carbonyl]aMino]-2-fluoro-4-hydroxybenzeneacetic Acid

Chemical Property:

• Boiling Point: 461.7±45.0 °C(Predicted)
• PKA: 3.43±0.10(Predicted)
• Density: 1.325±0.06 g/cm3(Predicted)

Purity/Quality:

α-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-fluoro-4-hydroxybenzeneaceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: α-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-fluoro-4-hydroxybenzeneacetic Acid was utilized in the preparation of oxadiazolypiperidines for the treatment of metabolic disorders.

Technology Process of α-[[(1,1-DiMethylethoxy)carbonyl]aMino]-2-fluoro-4-hydroxybenzeneacetic Acid

There total 1 articles about α-[[(1,1-DiMethylethoxy)carbonyl]aMino]-2-fluoro-4-hydroxybenzeneacetic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

amino-(2-fluoro-4-hydroxyphenyl)acetic acid hydrochloride (1131872-16-6) + di-tert-butyl dicarbonate (24424-99-5) → tert-butoxycarbonylamino-(2-fluoro-4-hydroxyphenyl)acetic acid (1131872-19-9)

Guidance literature:

amino-(2-fluoro-4-hydroxyphenyl)acetic acid hydrochloride; di-tert-butyl dicarbonate; With sodium carbonate; In 1,4-dioxane; water; at 20 ℃; for 2.7h;

With hydrogenchloride; water; In 1,4-dioxane; ethyl acetate;

upstream raw materials:

amino-(2-fluoro-4-hydroxyphenyl)acetic acid hydrochloride

di-tert-butyl dicarbonate

Refernces