ethyl N-[(benzyloxy)carbonyl]-3-(1-hydroxycyclopropyl)alaninate

Base Information

• Chemical Name: ethyl N-[(benzyloxy)carbonyl]-3-(1-hydroxycyclopropyl)alaninate
• CAS No.: 862205-18-3
• Molecular Formula: C₁₆H₂₁NO₅
• Molecular Weight: 307.346
• Mol file: 862205-18-3.mol

Synonyms:ethyl N-[(benzyloxy)carbonyl]-3-(1-hydroxycyclopropyl)alaninate

Chemical Property of ethyl N-[(benzyloxy)carbonyl]-3-(1-hydroxycyclopropyl)alaninate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl N-[(benzyloxy)carbonyl]-3-(1-hydroxycyclopropyl)alaninate

There total 2 articles about ethyl N-[(benzyloxy)carbonyl]-3-(1-hydroxycyclopropyl)alaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

ethyl 3-(1-hydroxycyclopropyl)alaninate (862205-14-9) + benzyl chloroformate (501-53-1,94274-21-2) → ethyl N-[(benzyloxy)carbonyl]-3-(1-hydroxycyclopropyl)alaninate (862205-18-3)

Guidance literature:

With sodium hydrogencarbonate; In water; acetone; at 0 ℃; for 3h;

DOI:10.1021/jo050640q

Reference yield:

ethyl 5-(phenylmethyl)-4-oxa-5-azaspiro[2.4]heptane-6-carboxylate (725238-54-0) → ethyl N-[(benzyloxy)carbonyl]-3-(1-hydroxycyclopropyl)alaninate (862205-18-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / H₂ / Pd(OH)2/C / methanol / 20 °C

2: 98 percent / NaHCO₃ / acetone; H₂O / 3 h / 0 °C

With hydrogen; sodium hydrogencarbonate; palladium dihydroxide; In methanol; water; acetone;

DOI:10.1021/jo050640q

Reference yield: 95.0%

ethyl N-[(benzyloxy)carbonyl]-3-(1-hydroxycyclopropyl)alaninate (862205-18-3) → ethyl 2-{[(benzyloxy)carbonyl]amino}-4-oxohex-5-enoate

Guidance literature:

With pyridine; oxygen; palladium diacetate; In toluene; at 80 ℃; for 3h; under 3800 Torr;

DOI:10.1021/jo050640q

upstream raw materials:

ethyl 3-(1-hydroxycyclopropyl)alaninate

benzyl chloroformate

ethyl 5-(phenylmethyl)-4-oxa-5-azaspiro[2.4]heptane-6-carboxylate