3-(5-amino-2-(2-methyl-4-(2-(2-(2-phosphonoethoxy)ethoxy)ethoxy)phenethyl) benzo[f][1,7]naphthyridin-8-yl)propanoic acid, L-arginine salt

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Chemical Name:3-(5-amino-2-(2-methyl-4-(2-(2-(2-phosphonoethoxy)ethoxy)ethoxy)phenethyl) benzo[f][1,7]naphthyridin-8-yl)propanoic acid, L-arginine salt
CAS No.:1454658-10-6
Molecular Formula:C₆H₁₄N₄O₂*C₃₀H₃₆N₃O₈P
Molecular Weight:771.808
Hs Code.:

Synonyms:3-(5-amino-2-(2-methyl-4-(2-(2-(2-phosphonoethoxy)ethoxy)ethoxy)phenethyl) benzo[f][1,7]naphthyridin-8-yl)propanoic acid, L-arginine salt

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Chemical Property of 3-(5-amino-2-(2-methyl-4-(2-(2-(2-phosphonoethoxy)ethoxy)ethoxy)phenethyl) benzo[f][1,7]naphthyridin-8-yl)propanoic acid, L-arginine salt

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Technology Process of 3-(5-amino-2-(2-methyl-4-(2-(2-(2-phosphonoethoxy)ethoxy)ethoxy)phenethyl) benzo[f][1,7]naphthyridin-8-yl)propanoic acid, L-arginine salt

There total 16 articles about 3-(5-amino-2-(2-methyl-4-(2-(2-(2-phosphonoethoxy)ethoxy)ethoxy)phenethyl) benzo[f][1,7]naphthyridin-8-yl)propanoic acid, L-arginine salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 74-79-3,25212-18-4
L-arginine

: 1258595-15-1
3-(5-amino-2-(2-methyl-4-(2-(2-(2-phosphonoethoxy)ethoxy)ethoxy)phenethyl) benzo[f][1,7]naphthyridin-8-yl)propanoic acid

: 1454658-10-6
3-(5-amino-2-(2-methyl-4-(2-(2-(2-phosphonoethoxy)ethoxy)ethoxy)phenethyl) benzo[f][1,7]naphthyridin-8-yl)propanoic acid, L-arginine salt

Guidance literature:: In methanol; water; at 50 ℃; for 1h;

Reference yield:

: 14472-14-1
4-bromo-3-methylphenol

: 1454658-10-6
3-(5-amino-2-(2-methyl-4-(2-(2-(2-phosphonoethoxy)ethoxy)ethoxy)phenethyl) benzo[f][1,7]naphthyridin-8-yl)propanoic acid, L-arginine salt

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

1.2: 3.5 h / 20 °C

2.1: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 60 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C

4.1: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 60 °C / Inert atmosphere

5.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; sodium hydrogencarbonate / butan-1-ol; water / 100 °C

6.1: palladium 10% on activated carbon; hydrogen / ethanol; tetrahydrofuran / 24 h

7.1: hydrogenchloride / ethanol; 1,4-dioxane / 3 h

8.1: caesium carbonate / N,N-dimethyl-formamide / 1.5 h / 60 °C

9.1: trimethylsilyl bromide / dichloromethane / 0 - 20 °C

9.2: 3 h / 80 °C

10.1: water; methanol / 1 h / 50 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; trimethylsilyl bromide; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; sodium hydrogencarbonate; caesium carbonate; triethylamine; XPhos; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; butan-1-ol;

Reference yield:

: 1258595-02-6
triethyl((4-(methoxymethoxy)-2-methylphenyl)ethynyl)silane

: 1454658-10-6
3-(5-amino-2-(2-methyl-4-(2-(2-(2-phosphonoethoxy)ethoxy)ethoxy)phenethyl) benzo[f][1,7]naphthyridin-8-yl)propanoic acid, L-arginine salt

Guidance literature:: Multi-step reaction with 8 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C

2.1: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 60 °C / Inert atmosphere

3.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; sodium hydrogencarbonate / butan-1-ol; water / 100 °C

4.1: palladium 10% on activated carbon; hydrogen / ethanol; tetrahydrofuran / 24 h

5.1: hydrogenchloride / ethanol; 1,4-dioxane / 3 h

6.1: caesium carbonate / N,N-dimethyl-formamide / 1.5 h / 60 °C

7.1: trimethylsilyl bromide / dichloromethane / 0 - 20 °C

7.2: 3 h / 80 °C

8.1: water; methanol / 1 h / 50 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; trimethylsilyl bromide; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; sodium hydrogencarbonate; caesium carbonate; triethylamine; XPhos; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; butan-1-ol;