Ethyl 4-chloro-6-methoxy-5-nitropyridine-3-carboxylate

Base Information

• Chemical Name: Ethyl 4-chloro-6-methoxy-5-nitropyridine-3-carboxylate
• CAS No.: 1210835-76-9
• Molecular Formula: C₉H₉ClN₂O₅
• Molecular Weight: 260.634
• Hs Code.: 2933399990
• Mol file: 1210835-76-9.mol

Synonyms:4-Chloro-6-methoxy-5-nitro-nicotinic acid ethyl ester

Chemical Property of Ethyl 4-chloro-6-methoxy-5-nitropyridine-3-carboxylate

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl 4-chloro-6-methoxy-5-nitropyridine-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Ethyl 4-Chloro-6-methoxy-5-nitropyridine-3-carboxylate could be a useful inhibitor of HIV-1 reverse transcriptase.

Technology Process of Ethyl 4-chloro-6-methoxy-5-nitropyridine-3-carboxylate

There total 1 articles about Ethyl 4-chloro-6-methoxy-5-nitropyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Me3O*BF4 + 4-Chloro-5-nitro-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid ethyl ester (1210835-74-7) → 4-Chloro-6-methoxy-5-nitro-nicotinic acid ethyl ester (1210835-76-9)

Guidance literature:

In dichloromethane; Reflux;

Reference yield:

4-Chloro-6-methoxy-5-nitro-nicotinic acid ethyl ester (1210835-76-9) + 3-bromo-5-chlorophenol (56962-04-0) → 4-(3-bromo-5-chloro-phenoxy)-6-methoxy-5-nitro-nicotinic acid ethyl ester (1210835-77-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 50 - 80 ℃; for 15h;

upstream raw materials:

4-Chloro-5-nitro-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid ethyl ester

Downstream raw materials:

4-(3-bromo-5-chloro-phenoxy)-6-methoxy-5-nitro-nicotinic acid ethyl ester

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