(3S,4R,5R,6R)-4,5-bis(benzyloxy)-6-(3'-triisopropylsilanyloxy-(S)-1'-hydroxypropyl)-piperidin-3-yl pivalate

Base Information

• Chemical Name: (3S,4R,5R,6R)-4,5-bis(benzyloxy)-6-(3'-triisopropylsilanyloxy-(S)-1'-hydroxypropyl)-piperidin-3-yl pivalate
• CAS No.: 1255955-56-6
• Molecular Formula: C₃₆H₅₇NO₆Si
• Molecular Weight: 627.937
• Mol file: 1255955-56-6.mol

Synonyms:(3S,4R,5R,6R)-4,5-bis(benzyloxy)-6-(3'-triisopropylsilanyloxy-(S)-1'-hydroxypropyl)-piperidin-3-yl pivalate

Chemical Property of (3S,4R,5R,6R)-4,5-bis(benzyloxy)-6-(3'-triisopropylsilanyloxy-(S)-1'-hydroxypropyl)-piperidin-3-yl pivalate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3S,4R,5R,6R)-4,5-bis(benzyloxy)-6-(3'-triisopropylsilanyloxy-(S)-1'-hydroxypropyl)-piperidin-3-yl pivalate

There total 1 articles about (3S,4R,5R,6R)-4,5-bis(benzyloxy)-6-(3'-triisopropylsilanyloxy-(S)-1'-hydroxypropyl)-piperidin-3-yl pivalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

(3R,4S,5R,6R)-4,5-bis(benzyloxy)-6-(3'-triisopropylsilanyloxy-(S)-1'-hydroxypropyl)-2-oxopiperidin-3-yl pivalate (1255955-55-5) → (3S,4R,5R,6R)-4,5-bis(benzyloxy)-6-(3'-triisopropylsilanyloxy-(S)-1'-hydroxypropyl)-piperidin-3-yl pivalate (1255955-56-6)

Guidance literature:

With borane-THF; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/ol102371x

Reference yield: 96.0%

(3S,4R,5R,6R)-4,5-bis(benzyloxy)-6-(3'-triisopropylsilanyloxy-(S)-1'-hydroxypropyl)-piperidin-3-yl pivalate (1255955-56-6) → (3S,4R,5R,6R)-4,5-bis(benzyloxy)-6-(3'-hydroxy-(S)-1'-hydroxypropyl)-piperidin-3-yl pivalate (1255955-57-7)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 2h; Inert atmosphere;

DOI:10.1021/ol102371x

upstream raw materials:

(3R,4S,5R,6R)-4,5-bis(benzyloxy)-6-(3'-triisopropylsilanyloxy-(S)-1'-hydroxypropyl)-2-oxopiperidin-3-yl pivalate

Downstream raw materials:

(3S,4R,5R,6R)-4,5-bis(benzyloxy)-6-(3'-hydroxy-(S)-1'-hydroxypropyl)-piperidin-3-yl pivalate