(1R,2R)-methyl 1-((S)-2-(tert-butoxycarbonylamino)butanamido)-2-(4'-fluorobiphenyl-4-yl)cyclopropanecarboxylate

Base Information

Chemical Name:(1R,2R)-methyl 1-((S)-2-(tert-butoxycarbonylamino)butanamido)-2-(4'-fluorobiphenyl-4-yl)cyclopropanecarboxylate
CAS No.:1401624-54-1
Molecular Formula:C₂₆H₃₁FN₂O₅
Molecular Weight:470.541
Hs Code.:

Synonyms:(1R,2R)-methyl 1-((S)-2-(tert-butoxycarbonylamino)butanamido)-2-(4'-fluorobiphenyl-4-yl)cyclopropanecarboxylate

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Chemical Property of (1R,2R)-methyl 1-((S)-2-(tert-butoxycarbonylamino)butanamido)-2-(4'-fluorobiphenyl-4-yl)cyclopropanecarboxylate

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Technology Process of (1R,2R)-methyl 1-((S)-2-(tert-butoxycarbonylamino)butanamido)-2-(4'-fluorobiphenyl-4-yl)cyclopropanecarboxylate

There total 5 articles about (1R,2R)-methyl 1-((S)-2-(tert-butoxycarbonylamino)butanamido)-2-(4'-fluorobiphenyl-4-yl)cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1401624-53-0
(1R,2R)-methyl 1-amino-2-(4-fluorobipheny-4-yl)cyclopropanecarboxylate

: 34306-42-8
Boc-Abu

: 1401624-54-1
(1R,2R)-methyl 1-((S)-2-(tert-butoxycarbonylamino)butanamido)-2-(4'-fluorobiphenyl-4-yl)cyclopropanecarboxylate

Guidance literature:: Boc-Abu; With 4-methyl-morpholine; chloroformic acid ethyl ester; In dichloromethane; at 0 ℃; for 0.5h;

(1R,2R)-methyl 1-amino-2-(4-fluorobipheny-4-yl)cyclopropanecarboxylate; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 128376-64-7
4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde

: 1401624-54-1
(1R,2R)-methyl 1-((S)-2-(tert-butoxycarbonylamino)butanamido)-2-(4'-fluorobiphenyl-4-yl)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 20 °C / Inert atmosphere; Reflux

2.1: methanol / 0.5 h / 20 °C

3.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C

3.2: 96 h / 50 °C / Inert atmosphere

4.1: hydrogenchloride / ethyl acetate; water / 0.5 h / 20 °C

5.1: chloroformic acid ethyl ester; 4-methyl-morpholine / dichloromethane / 0.5 h / 0 °C

5.2: 2 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; n-butyllithium; chloroformic acid ethyl ester; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; toluene;

Reference yield:

: 460-00-4
1-Bromo-4-fluorobenzene

: 1401624-54-1
(1R,2R)-methyl 1-((S)-2-(tert-butoxycarbonylamino)butanamido)-2-(4'-fluorobiphenyl-4-yl)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 20 °C / Inert atmosphere; Reflux

2.1: methanol / 0.5 h / 20 °C

3.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C

3.2: 96 h / 50 °C / Inert atmosphere

4.1: hydrogenchloride / ethyl acetate; water / 0.5 h / 20 °C

5.1: chloroformic acid ethyl ester; 4-methyl-morpholine / dichloromethane / 0.5 h / 0 °C

5.2: 2 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; n-butyllithium; chloroformic acid ethyl ester; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; toluene;