rac-3-(tert-butyloxycarbonyl)-4-(3-bromo-phenyl)-4-methyl-[1,1,3]oxathiazolidine 2-oxide

Base Information

Chemical Name:rac-3-(tert-butyloxycarbonyl)-4-(3-bromo-phenyl)-4-methyl-[1,1,3]oxathiazolidine 2-oxide
CAS No.:887913-70-4
Molecular Formula:C₁₄H₁₈BrNO₄S
Molecular Weight:376.271
Hs Code.:

Synonyms:rac-3-(tert-butyloxycarbonyl)-4-(3-bromo-phenyl)-4-methyl-[1,1,3]oxathiazolidine 2-oxide

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Chemical Property of rac-3-(tert-butyloxycarbonyl)-4-(3-bromo-phenyl)-4-methyl-[1,1,3]oxathiazolidine 2-oxide

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Technology Process of rac-3-(tert-butyloxycarbonyl)-4-(3-bromo-phenyl)-4-methyl-[1,1,3]oxathiazolidine 2-oxide

There total 5 articles about rac-3-(tert-butyloxycarbonyl)-4-(3-bromo-phenyl)-4-methyl-[1,1,3]oxathiazolidine 2-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 887913-69-1
rac-[1-(3-bromo-phenyl)-2-hydroxy-1-methyl-ethyl]-carbamic acid tert-butyl ester

: 887913-70-4
rac-3-(tert-butyloxycarbonyl)-4-(3-bromo-phenyl)-4-methyl-[1,1,3]oxathiazolidine 2-oxide

Guidance literature:: With pyridine; thionyl chloride; In acetonitrile; at -40 - 20 ℃; for 64.5h; Inert atmosphere;

Reference yield:

: 1183581-39-6
(RS)-2-amino-2-(3-bromo-phenyl)-propionic acid methyl ester

: 887913-70-4
rac-3-(tert-butyloxycarbonyl)-4-(3-bromo-phenyl)-4-methyl-[1,1,3]oxathiazolidine 2-oxide

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 1 h / -15 - 0 °C

2.1: sodium hydrogencarbonate / tetrahydrofuran / 15 h / 0 - 20 °C

2.2: pH 1 - 2 / Cooling with ice

3.1: thionyl chloride; pyridine / acetonitrile / 64.5 h / -40 - 20 °C / Inert atmosphere

With pyridine; thionyl chloride; sodium hydrogencarbonate; In tetrahydrofuran; acetonitrile;

Reference yield:

: 2142-63-4
1-(3-Bromophenyl)ethanone

: 887913-70-4
rac-3-(tert-butyloxycarbonyl)-4-(3-bromo-phenyl)-4-methyl-[1,1,3]oxathiazolidine 2-oxide

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonia; ammonium chloride / methanol / 96 h / 20 °C

2.1: hydrogenchloride / 4 h / Reflux

3.1: tetrahydrofuran / 1 h / -15 - 0 °C

4.1: sodium hydrogencarbonate / tetrahydrofuran / 15 h / 0 - 20 °C

4.2: pH 1 - 2 / Cooling with ice

5.1: thionyl chloride; pyridine / acetonitrile / 64.5 h / -40 - 20 °C / Inert atmosphere

With pyridine; hydrogenchloride; thionyl chloride; ammonia; sodium hydrogencarbonate; ammonium chloride; In tetrahydrofuran; methanol; acetonitrile;