1-[2,4-dimethyl-5-(4-(3-(4-iodophenyl)adamantanyl)phenyl)thiophen-3-yl]-2-(2-methoxy-4-methyl-5-phenylthiophen-3-yl)-3,3,4,4,5,5-hexafluorocyclopentene

Base Information

Chemical Name:1-[2,4-dimethyl-5-(4-(3-(4-iodophenyl)adamantanyl)phenyl)thiophen-3-yl]-2-(2-methoxy-4-methyl-5-phenylthiophen-3-yl)-3,3,4,4,5,5-hexafluorocyclopentene
CAS No.:811830-68-9
Molecular Formula:C₄₅H₃₉F₆IOS₂
Molecular Weight:900.831
Hs Code.:

1-[2,4-dimethyl-5-(4-(3-(4-iodophenyl)adamantanyl)phenyl)thiophen-3-yl]-2-(2-methoxy-4-methyl-5-phenylthiophen-3-yl)-3,3,4,4,5,5-hexafluorocyclopentene

Synonyms:1-[2,4-dimethyl-5-(4-(3-(4-iodophenyl)adamantanyl)phenyl)thiophen-3-yl]-2-(2-methoxy-4-methyl-5-phenylthiophen-3-yl)-3,3,4,4,5,5-hexafluorocyclopentene

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Chemical Property of 1-[2,4-dimethyl-5-(4-(3-(4-iodophenyl)adamantanyl)phenyl)thiophen-3-yl]-2-(2-methoxy-4-methyl-5-phenylthiophen-3-yl)-3,3,4,4,5,5-hexafluorocyclopentene

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Technology Process of 1-[2,4-dimethyl-5-(4-(3-(4-iodophenyl)adamantanyl)phenyl)thiophen-3-yl]-2-(2-methoxy-4-methyl-5-phenylthiophen-3-yl)-3,3,4,4,5,5-hexafluorocyclopentene

There total 9 articles about 1-[2,4-dimethyl-5-(4-(3-(4-iodophenyl)adamantanyl)phenyl)thiophen-3-yl]-2-(2-methoxy-4-methyl-5-phenylthiophen-3-yl)-3,3,4,4,5,5-hexafluorocyclopentene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 83102-75-4
1,3-bis(4-iododiphenyl)adamantane

: 811830-61-2
1-(2-methoxy-4-methyl-5-phenylthiophen-3-yl)-2-(2,4-dimethyl-5-bromothiophen-3-yl)-3,3,4,4,5,5-hexafluorocyclopentene

: 811830-68-9
1-[2,4-dimethyl-5-(4-(3-(4-iodophenyl)adamantanyl)phenyl)thiophen-3-yl]-2-(2-methoxy-4-methyl-5-phenylthiophen-3-yl)-3,3,4,4,5,5-hexafluorocyclopentene

Guidance literature:: 1-(2-methoxy-4-methyl-5-phenylthiophen-3-yl)-2-(2,4-dimethyl-5-bromothiophen-3-yl)-3,3,4,4,5,5-hexafluorocyclopentene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃;

With boric acid tributyl ester; In tetrahydrofuran; hexane; at -78 - 20 ℃;

1,3-bis(4-iododiphenyl)adamantane; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; hexane; Heating;
DOI:10.1021/ja047169n

Reference yield:

: 40189-21-7
1,3-Diphenyladamantane

: 811830-68-9
1-[2,4-dimethyl-5-(4-(3-(4-iodophenyl)adamantanyl)phenyl)thiophen-3-yl]-2-(2-methoxy-4-methyl-5-phenylthiophen-3-yl)-3,3,4,4,5,5-hexafluorocyclopentene

Guidance literature:: Multi-step reaction with 2 steps

1.1: 80 percent / I₂; H₅IO₆; H₂SO₄ / aq. AcOH / 4 h / 65 °C

2.1: n-BuLi / tetrahydrofuran; hexane / -78 °C

2.2: tri-n-butylborate / tetrahydrofuran; hexane / -78 - 20 °C

2.3: 28 percent / aq. Na₂CO₃; Pd(PPh₃)4 / tetrahydrofuran; hexane / Heating

With n-butyllithium; sulfuric acid; iodine; periodic acid; acetic acid; In tetrahydrofuran; hexane; 2.2: Suzuki coupling;
DOI:10.1021/ja047169n

Reference yield:

: 63862-00-0
2,4-dibromo-3,5-dimethylthiophene

: 811830-68-9
1-[2,4-dimethyl-5-(4-(3-(4-iodophenyl)adamantanyl)phenyl)thiophen-3-yl]-2-(2-methoxy-4-methyl-5-phenylthiophen-3-yl)-3,3,4,4,5,5-hexafluorocyclopentene

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-BuLi / tetrahydrofuran; hexane / -78 °C

1.2: tetrahydrofuran; hexane / -78 - 20 °C

2.1: n-BuLi / tetrahydrofuran; hexane / -78 °C

2.2: 78 percent / tetrahydrofuran; hexane / -78 - 20 °C

3.1: tetrabutylammonium fluoride / tetrahydrofuran / 20 °C

4.1: 0.74 g / NBS / tetrahydrofuran / 2 h

5.1: n-BuLi / tetrahydrofuran; hexane / -78 °C

5.2: tri-n-butylborate / tetrahydrofuran; hexane / -78 - 20 °C

5.3: 28 percent / aq. Na₂CO₃; Pd(PPh₃)4 / tetrahydrofuran; hexane / Heating

With N-Bromosuccinimide; n-butyllithium; tetrabutyl ammonium fluoride; In tetrahydrofuran; hexane; 5.2: Suzuki coupling;
DOI:10.1021/ja047169n