N-(N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)carbamimidoyl)-3,4,5-trimethoxybenzamide

Base Information

Chemical Name:N-(N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)carbamimidoyl)-3,4,5-trimethoxybenzamide
CAS No.:1263131-96-9
Molecular Formula:C₂₂H₂₁N₅O₄S
Molecular Weight:451.506
Hs Code.:

Synonyms:N-(N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)carbamimidoyl)-3,4,5-trimethoxybenzamide

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Chemical Property of N-(N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)carbamimidoyl)-3,4,5-trimethoxybenzamide

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Technology Process of N-(N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)carbamimidoyl)-3,4,5-trimethoxybenzamide

There total 6 articles about N-(N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)carbamimidoyl)-3,4,5-trimethoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1192928-32-7
N-(3-(imidazo[2,1-b]thiazol-6-yl)phenylcarbamothioyl)-3,4,5-trimethoxybenzamide

: 1263131-96-9
N-(N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)carbamimidoyl)-3,4,5-trimethoxybenzamide

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1,1,1,3,3,3-hexamethyl-disilazane; In acetonitrile; at 20 ℃; for 5h; Inert atmosphere; Cooling with ice;
DOI:10.1021/jm2013369

Reference yield:

: 6-(3-nitrophenyl)imidazo[2,1-b]thiazole

: 1263131-96-9
N-(N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)carbamimidoyl)-3,4,5-trimethoxybenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; ammonium formate / isopropyl alcohol / Inert atmosphere; Microwave irradiation

2: acetone / 1 h / Inert atmosphere; Reflux

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1,1,1,3,3,3-hexamethyl-disilazane / acetonitrile / 5 h / 20 °C / Inert atmosphere; Cooling with ice

With palladium 10% on activated carbon; ammonium formate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1,1,1,3,3,3-hexamethyl-disilazane; In isopropyl alcohol; acetone; acetonitrile;
DOI:10.1021/jm2013369

Reference yield:

: 4521-61-3
3,4,5-Trimethoxybenzoyl chloride

: 1263131-96-9
N-(N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)carbamimidoyl)-3,4,5-trimethoxybenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: acetone / 0.33 h / Inert atmosphere; Reflux

2: acetone / 1 h / Inert atmosphere; Reflux

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1,1,1,3,3,3-hexamethyl-disilazane / acetonitrile / 5 h / 20 °C / Inert atmosphere; Cooling with ice

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1,1,1,3,3,3-hexamethyl-disilazane; In acetone; acetonitrile;
DOI:10.1021/jm2013369