2-[2-(5-bromo-2-methoxy-phenyl)-ethyl]-thiophene-3-carboxylic acid

Base Information

• Chemical Name: 2-[2-(5-bromo-2-methoxy-phenyl)-ethyl]-thiophene-3-carboxylic acid
• CAS No.: 705979-23-3
• Molecular Formula: C₁₄H₁₃BrO₃S
• Molecular Weight: 341.225
• Mol file: 705979-23-3.mol

Synonyms:2-[2-(5-bromo-2-methoxy-phenyl)-ethyl]-thiophene-3-carboxylic acid

Chemical Property of 2-[2-(5-bromo-2-methoxy-phenyl)-ethyl]-thiophene-3-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[2-(5-bromo-2-methoxy-phenyl)-ethyl]-thiophene-3-carboxylic acid

There total 1 articles about 2-[2-(5-bromo-2-methoxy-phenyl)-ethyl]-thiophene-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

2-bromo-5-methoxybenzyl bromide (19614-12-1) → 2-[2-(5-bromo-2-methoxy-phenyl)-ethyl]-thiophene-3-carboxylic acid (705979-23-3)

Guidance literature:

2-methylthiophene-3-carboxylic acid; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1h;

2-bromo-5-methoxybenzyl bromide; In tetrahydrofuran; at -78 - 20 ℃; for 1h;

Reference yield:

2-[2-(5-bromo-2-methoxy-phenyl)-ethyl]-thiophene-3-carboxylic acid (705979-23-3) → N-{2-[2-(5-bromo-2-methoxy-phenyl)-ethyl]-thiophene-3-carbonyl}-N'-(4-diethylamino-1-methyl-butyl)-guanidine

Guidance literature:

Multi-step reaction with 3 steps

1: SOCl₂ / 1 h / Heating

2: aq. NaOH / 3.5 h / 0 °C

3: Et₃N / o-xylene / 4 h / 145 °C

With sodium hydroxide; thionyl chloride; triethylamine; In o-xylene;

DOI:10.1016/j.bmcl.2006.01.016

Reference yield:

2-[2-(5-bromo-2-methoxy-phenyl)-ethyl]-thiophene-3-carboxylic acid (705979-23-3) → 2-[2-(5-bromo-2-methoxy-phenyl)-ethyl]-thiophene-3-carbonyl chloride

Guidance literature:

With thionyl chloride; for 1h; Heating;

DOI:10.1016/j.bmcl.2006.01.016

upstream raw materials:

2-bromo-5-methoxybenzyl bromide

Downstream raw materials:

1-{2-[2-(5-bromo-2-methoxy-phenyl)-ethyl]-thiophene-3-carbonyl}-2-methyl-isothiourea