4-(4-(1-(cyanomethyl)-3-(3-methoxy-5-methylphenyl)-1H-pyrazol-4-yl)pyridin-2-yl)benzonitrile

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Chemical Name:4-(4-(1-(cyanomethyl)-3-(3-methoxy-5-methylphenyl)-1H-pyrazol-4-yl)pyridin-2-yl)benzonitrile
CAS No.:1192885-66-7
Molecular Formula:C₂₅H₁₉N₅O
Molecular Weight:405.459
Hs Code.:

Synonyms:4-(4-(1-(cyanomethyl)-3-(3-methoxy-5-methylphenyl)-1H-pyrazol-4-yl)pyridin-2-yl)benzonitrile

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Chemical Property of 4-(4-(1-(cyanomethyl)-3-(3-methoxy-5-methylphenyl)-1H-pyrazol-4-yl)pyridin-2-yl)benzonitrile

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Technology Process of 4-(4-(1-(cyanomethyl)-3-(3-methoxy-5-methylphenyl)-1H-pyrazol-4-yl)pyridin-2-yl)benzonitrile

There total 6 articles about 4-(4-(1-(cyanomethyl)-3-(3-methoxy-5-methylphenyl)-1H-pyrazol-4-yl)pyridin-2-yl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 624-75-9
iodoacetonitrile

: 1192885-45-2
2-chloro-4-(3-(3-methoxy-5-methylphenyl)-1H-pyrazol-4-yl)pyridine

: 126747-14-6
4-cyanophenylboronic acid

: 1192885-66-7
4-(4-(1-(cyanomethyl)-3-(3-methoxy-5-methylphenyl)-1H-pyrazol-4-yl)pyridin-2-yl)benzonitrile

Guidance literature:: 2-chloro-4-(3-(3-methoxy-5-methylphenyl)-1H-pyrazol-4-yl)pyridine; With potassium carbonate; In acetone; for 2h; Reflux;

iodoacetonitrile; In acetone; for 2h; Reflux;

4-cyanophenylboronic acid; With potassium carbonate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; water; at 70 ℃; for 12h; Inert atmosphere;

Reference yield:

: 624-75-9
iodoacetonitrile

: 1192885-45-2
2-chloro-4-(3-(3-methoxy-5-methylphenyl)-1H-pyrazol-4-yl)pyridine

: 126747-14-6
4-cyanophenylboronic acid

: 1192885-66-7
4-(4-(1-(cyanomethyl)-3-(3-methoxy-5-methylphenyl)-1H-pyrazol-4-yl)pyridin-2-yl)benzonitrile

: 1192885-84-9
4-(4-(1-(cyanomethyl)-5-(3-methoxy-5-methylphenyl)-1H-pyrazol-4-yl)pyridin-2-yl)benzonitrile

Guidance literature:: iodoacetonitrile; 2-chloro-4-(3-(3-methoxy-5-methylphenyl)-1H-pyrazol-4-yl)pyridine; With potassium carbonate; In acetone; for 4h; Reflux;

4-cyanophenylboronic acid; With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In tetrahydrofuran; water; at 70 ℃; for 12h; Inert atmosphere;
DOI:10.1016/j.bmcl.2009.08.029

Reference yield:

: 585-81-9
3-hydroxy-5-methylbenzoic acid

: 1192885-66-7
4-(4-(1-(cyanomethyl)-3-(3-methoxy-5-methylphenyl)-1H-pyrazol-4-yl)pyridin-2-yl)benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / dmap / acetone / 12 h / 65 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3.1: 12 h / Reflux

3.2: 2 h / 20 °C

4.1: potassium carbonate / acetone / 2 h / Reflux

4.2: 2 h / Reflux

4.3: 12 h / 70 °C / Inert atmosphere

With potassium carbonate; lithium hexamethyldisilazane; dmap; In tetrahydrofuran; acetone;