1-[2-((4-Z-piperazin-1-yl)carbonyl)-4-(tert-butyldiphenylsilyloxy)butyl]uracil

Base Information

Chemical Name:1-[2-((4-Z-piperazin-1-yl)carbonyl)-4-(tert-butyldiphenylsilyloxy)butyl]uracil
CAS No.:1305264-73-6
Molecular Formula:C₃₇H₄₄N₄O₆Si
Molecular Weight:668.865
Hs Code.:

Synonyms:1-[2-((4-Z-piperazin-1-yl)carbonyl)-4-(tert-butyldiphenylsilyloxy)butyl]uracil

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[2-((4-Z-piperazin-1-yl)carbonyl)-4-(tert-butyldiphenylsilyloxy)butyl]uracil

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Technology Process of 1-[2-((4-Z-piperazin-1-yl)carbonyl)-4-(tert-butyldiphenylsilyloxy)butyl]uracil

There total 2 articles about 1-[2-((4-Z-piperazin-1-yl)carbonyl)-4-(tert-butyldiphenylsilyloxy)butyl]uracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 31166-44-6
phenylmethyl 1-piperazinecarboxylate

: 1305264-66-7
1-[2-(carboxy)-4-(tert-butyldiphenylsilyloxy)butyl]uracil

: 1305264-73-6
1-[2-((4-Z-piperazin-1-yl)carbonyl)-4-(tert-butyldiphenylsilyloxy)butyl]uracil

Guidance literature:: With triethylamine; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmc.2011.02.012

Reference yield:

: 1305264-64-5
C₂₅H₃₂N₂O₄Si

: 1305264-73-6
1-[2-((4-Z-piperazin-1-yl)carbonyl)-4-(tert-butyldiphenylsilyloxy)butyl]uracil

Guidance literature:: Multi-step reaction with 2 steps

1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene / water; acetonitrile / 3 h / 20 °C

2: triethylamine; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; triethylamine; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; dicyclohexyl-carbodiimide; In water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2011.02.012