Technology Process of methyl 4-bromo-3-fluoro-2-(trifluoromethyl)benzoate
There total 3 articles about methyl 4-bromo-3-fluoro-2-(trifluoromethyl)benzoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
methyl 4-amino-3-fluoro-2-(trifluoromethyl)benzoate;
With
hydrogen bromide;
In
water; acetonitrile;
at 0 ℃;
for 0.166667h;
With
sodium nitrite;
In
water; acetonitrile;
at 0 ℃;
for 1.08333h;
With
copper(I) bromide;
In
water; acetonitrile;
at 0 - 70 ℃;
for 1.5h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 1 h / 15 - 20 °C / Inert atmosphere
2.1: triethylamine / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / dimethyl sulfoxide / 16 h / 80 °C / 37503.8 Torr
3.1: hydrogen bromide / acetonitrile; water / 0.17 h / 0 °C
3.2: 1.08 h / 0 °C
3.3: 1.5 h / 0 - 70 °C
With
N-Bromosuccinimide; hydrogen bromide; triethylamine;
1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate;
In
water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: triethylamine / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / dimethyl sulfoxide / 16 h / 80 °C / 37503.8 Torr
2.1: hydrogen bromide / acetonitrile; water / 0.17 h / 0 °C
2.2: 1.08 h / 0 °C
2.3: 1.5 h / 0 - 70 °C
With
hydrogen bromide; triethylamine;
1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate;
In
water; dimethyl sulfoxide; acetonitrile;
