3-(6-bromo-pyridin-3-yl)-3-(3-cyclobutoxy-4-difluoromethoxy-phenyl)-2-pyridin-4-yl-propionic acid ethyl ester

Base Information

Chemical Name:3-(6-bromo-pyridin-3-yl)-3-(3-cyclobutoxy-4-difluoromethoxy-phenyl)-2-pyridin-4-yl-propionic acid ethyl ester
CAS No.:1027864-06-7
Molecular Formula:C₂₆H₂₅BrF₂N₂O₄
Molecular Weight:547.396
Hs Code.:

Synonyms:3-(6-bromo-pyridin-3-yl)-3-(3-cyclobutoxy-4-difluoromethoxy-phenyl)-2-pyridin-4-yl-propionic acid ethyl ester

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Chemical Property of 3-(6-bromo-pyridin-3-yl)-3-(3-cyclobutoxy-4-difluoromethoxy-phenyl)-2-pyridin-4-yl-propionic acid ethyl ester

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Technology Process of 3-(6-bromo-pyridin-3-yl)-3-(3-cyclobutoxy-4-difluoromethoxy-phenyl)-2-pyridin-4-yl-propionic acid ethyl ester

There total 4 articles about 3-(6-bromo-pyridin-3-yl)-3-(3-cyclobutoxy-4-difluoromethoxy-phenyl)-2-pyridin-4-yl-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 54401-85-3
pyridin-4-yl-acetic acid ethyl ester

: 290307-29-8
2-bromo-5-[chloro-(3-cyclobutoxy-4-difluoromethoxy-phenyl)-methyl]-pyridine

: 1027864-06-7
3-(6-bromo-pyridin-3-yl)-3-(3-cyclobutoxy-4-difluoromethoxy-phenyl)-2-pyridin-4-yl-propionic acid ethyl ester

Guidance literature:: pyridin-4-yl-acetic acid ethyl ester; With potassium hexamethylsilazane; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; for 0.333333h;

2-bromo-5-[chloro-(3-cyclobutoxy-4-difluoromethoxy-phenyl)-methyl]-pyridine; In tetrahydrofuran; at 20 ℃; for 15h;
DOI:10.1021/jm0204542

Reference yield:

: 624-28-2
2,5-dibromopyridine

: 1027864-06-7
3-(6-bromo-pyridin-3-yl)-3-(3-cyclobutoxy-4-difluoromethoxy-phenyl)-2-pyridin-4-yl-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi / diethyl ether; hexane / 0.75 h / -78 °C

1.2: 90 percent / diethyl ether; hexane / 2 h

2.1: SOCl₂ / CH₂Cl₂ / 0.75 h / 20 °C

3.1: KHMDS / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.33 h

3.2: tetrahydrofuran / 15 h / 20 °C

With n-butyllithium; thionyl chloride; potassium hexamethylsilazane; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; hexane; dichloromethane;
DOI:10.1021/jm0204542

Reference yield:

: 290307-39-0
3-cyclobutoxy-4-difluoromethoxy-benzaldehyde

: 1027864-06-7
3-(6-bromo-pyridin-3-yl)-3-(3-cyclobutoxy-4-difluoromethoxy-phenyl)-2-pyridin-4-yl-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi / diethyl ether; hexane / 0.75 h / -78 °C

1.2: 90 percent / diethyl ether; hexane / 2 h

2.1: SOCl₂ / CH₂Cl₂ / 0.75 h / 20 °C

3.1: KHMDS / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.33 h

3.2: tetrahydrofuran / 15 h / 20 °C

With n-butyllithium; thionyl chloride; potassium hexamethylsilazane; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; hexane; dichloromethane;
DOI:10.1021/jm0204542