propan-2-yl N-{2-[(tert-butoxycarbonyl)amino]-2-(3,5-difluorophenyl)propyl}-O-[tert-butyl(dimethyl)silyl]-2-methylserinate

Base Information

Chemical Name:propan-2-yl N-{2-[(tert-butoxycarbonyl)amino]-2-(3,5-difluorophenyl)propyl}-O-[tert-butyl(dimethyl)silyl]-2-methylserinate
CAS No.:1189569-93-4
Molecular Formula:C₂₇H₄₆F₂N₂O₅Si
Molecular Weight:544.755
Hs Code.:

Synonyms:propan-2-yl N-{2-[(tert-butoxycarbonyl)amino]-2-(3,5-difluorophenyl)propyl}-O-[tert-butyl(dimethyl)silyl]-2-methylserinate

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Chemical Property of propan-2-yl N-{2-[(tert-butoxycarbonyl)amino]-2-(3,5-difluorophenyl)propyl}-O-[tert-butyl(dimethyl)silyl]-2-methylserinate

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Technology Process of propan-2-yl N-{2-[(tert-butoxycarbonyl)amino]-2-(3,5-difluorophenyl)propyl}-O-[tert-butyl(dimethyl)silyl]-2-methylserinate

There total 6 articles about propan-2-yl N-{2-[(tert-butoxycarbonyl)amino]-2-(3,5-difluorophenyl)propyl}-O-[tert-butyl(dimethyl)silyl]-2-methylserinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 957122-15-5
tert-butyl [1-(3,5-difluorophenyl)-1-methyl-2-oxoethyl]carbamate

: 1189569-91-2
methyl O-[(tert-butyl)(dimethyl)silyl]-2-methylserinate

: 1189569-92-3
methyl N-{2-[(tert-butoxycarbonyl)amino]-2-(3,5-difluorophenyl)propyl}-O-[tert-butyl(dimethyl)silyl]-2-methylserinate

: 1189569-93-4
propan-2-yl N-{2-[(tert-butoxycarbonyl)amino]-2-(3,5-difluorophenyl)propyl}-O-[tert-butyl(dimethyl)silyl]-2-methylserinate

Guidance literature:: tert-butyl [1-(3,5-difluorophenyl)-1-methyl-2-oxoethyl]carbamate; methyl O-[(tert-butyl)(dimethyl)silyl]-2-methylserinate; titanium(IV) isopropylate; In ethyl acetate; at 20 ℃; for 2h;

With sodium cyanoborohydride; acetic acid; In methanol; at 0 - 20 ℃; for 0.533333h; Cooling;

Reference yield:

: 321318-29-0,444643-16-7,771465-40-8
1-(3,5-difluorophenyl)ethylamine

: 1189569-92-3
methyl N-{2-[(tert-butoxycarbonyl)amino]-2-(3,5-difluorophenyl)propyl}-O-[tert-butyl(dimethyl)silyl]-2-methylserinate

: 1189569-93-4
propan-2-yl N-{2-[(tert-butoxycarbonyl)amino]-2-(3,5-difluorophenyl)propyl}-O-[tert-butyl(dimethyl)silyl]-2-methylserinate

Guidance literature:: Multi-step reaction with 4 steps

1.1: dichloromethane / 0 - 20 °C

1.2: 60 - 70 °C

2.1: potassium tert-butylate / tetrahydrofuran / -78 - 20 °C

2.2: -78 - 0 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / -78 °C

4.1: titanium(IV) isopropylate / ethyl acetate / 2 h / 20 °C

4.2: 0.53 h / 0 - 20 °C / Cooling

With lithium aluminium tetrahydride; potassium tert-butylate; titanium(IV) isopropylate; In tetrahydrofuran; dichloromethane; ethyl acetate;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1189569-92-3
methyl N-{2-[(tert-butoxycarbonyl)amino]-2-(3,5-difluorophenyl)propyl}-O-[tert-butyl(dimethyl)silyl]-2-methylserinate

: 1189569-93-4
propan-2-yl N-{2-[(tert-butoxycarbonyl)amino]-2-(3,5-difluorophenyl)propyl}-O-[tert-butyl(dimethyl)silyl]-2-methylserinate

Guidance literature:: Multi-step reaction with 4 steps

1.1: dichloromethane / 0 - 20 °C

1.2: 60 - 70 °C

2.1: potassium tert-butylate / tetrahydrofuran / -78 - 20 °C

2.2: -78 - 0 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / -78 °C

4.1: titanium(IV) isopropylate / ethyl acetate / 2 h / 20 °C

4.2: 0.53 h / 0 - 20 °C / Cooling

With lithium aluminium tetrahydride; potassium tert-butylate; titanium(IV) isopropylate; In tetrahydrofuran; dichloromethane; ethyl acetate;