N-(1-isopropylpiperidin-4-yl)-6-(1-(4-methoxybenzyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)pyrazin-2-amine

Base Information

Chemical Name:N-(1-isopropylpiperidin-4-yl)-6-(1-(4-methoxybenzyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)pyrazin-2-amine
CAS No.:1401732-41-9
Molecular Formula:C₂₇H₃₃N₇O
Molecular Weight:471.605
Hs Code.:

Synonyms:N-(1-isopropylpiperidin-4-yl)-6-(1-(4-methoxybenzyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)pyrazin-2-amine

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Chemical Property of N-(1-isopropylpiperidin-4-yl)-6-(1-(4-methoxybenzyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)pyrazin-2-amine

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Technology Process of N-(1-isopropylpiperidin-4-yl)-6-(1-(4-methoxybenzyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)pyrazin-2-amine

There total 6 articles about N-(1-isopropylpiperidin-4-yl)-6-(1-(4-methoxybenzyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)pyrazin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1111638-43-7
1-(4-methoxybenzyl)-3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazolo[3,4-b]pyridine

: 1401732-40-8
6-chloro-N-(1-isopropylpiperidin-4-yl)pyrazin-2-amine

: 1401732-41-9
N-(1-isopropylpiperidin-4-yl)-6-(1-(4-methoxybenzyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)pyrazin-2-amine

Guidance literature:: With caesium carbonate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; In N,N-dimethyl-formamide; at 100 ℃; Inert atmosphere; Sealed tube;

Reference yield:

: 534596-29-7
1-Isopropyl-piperidin-4-ylamine hydrochloride

: 1401732-41-9
N-(1-isopropylpiperidin-4-yl)-6-(1-(4-methoxybenzyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)pyrazin-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 100 °C / Inert atmosphere

2: caesium carbonate / palladium bis[bis(diphenylphosphino)ferrocene] dichloride / N,N-dimethyl-formamide / 100 °C / Inert atmosphere; Sealed tube

With caesium carbonate; N-ethyl-N,N-diisopropylamine; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; In N,N-dimethyl-formamide;

Reference yield:

: 62908-83-2
3-methyl-5-nitropyrazolo<3,4-b>pyridine

: 1401732-41-9
N-(1-isopropylpiperidin-4-yl)-6-(1-(4-methoxybenzyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)pyrazin-2-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: palladium on activated charcoal / ethanol / 5 h / 20 °C

2.1: hydrogen bromide; sodium nitrite / copper(I) bromide / water / 4 h / -5 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / -5 - 20 °C

3.2: 0 - 20 °C / Reflux

4.1: potassium acetate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 90 °C / Inert atmosphere

5.1: caesium carbonate / palladium bis[bis(diphenylphosphino)ferrocene] dichloride / N,N-dimethyl-formamide / 100 °C / Inert atmosphere; Sealed tube

With hydrogen bromide; potassium acetate; sodium hydride; caesium carbonate; sodium nitrite; bis-triphenylphosphine-palladium(II) chloride; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; palladium on activated charcoal; copper(I) bromide; In ethanol; water; N,N-dimethyl-formamide; mineral oil;