2-(4-(3-(2-(diethylamino)-2-oxoethyl)-5,7-diethylpyrazolo[1,5-a]pyrimidin-2-yl)phenoxy)ethyl 4-methylbenzenesulfonate

Base Information

• Chemical Name: 2-(4-(3-(2-(diethylamino)-2-oxoethyl)-5,7-diethylpyrazolo[1,5-a]pyrimidin-2-yl)phenoxy)ethyl 4-methylbenzenesulfonate
• CAS No.: 1428949-92-1
• Molecular Formula: C₃₁H₃₈N₄O₅S
• Molecular Weight: 578.733
• Mol file: 1428949-92-1.mol

Synonyms:2-(4-(3-(2-(diethylamino)-2-oxoethyl)-5,7-diethylpyrazolo[1,5-a]pyrimidin-2-yl)phenoxy)ethyl 4-methylbenzenesulfonate

Chemical Property of 2-(4-(3-(2-(diethylamino)-2-oxoethyl)-5,7-diethylpyrazolo[1,5-a]pyrimidin-2-yl)phenoxy)ethyl 4-methylbenzenesulfonate

Chemical Property:

Purity/Quality:

99%,98%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-(3-(2-(diethylamino)-2-oxoethyl)-5,7-diethylpyrazolo[1,5-a]pyrimidin-2-yl)phenoxy)ethyl 4-methylbenzenesulfonate

There total 10 articles about 2-(4-(3-(2-(diethylamino)-2-oxoethyl)-5,7-diethylpyrazolo[1,5-a]pyrimidin-2-yl)phenoxy)ethyl 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(5,7-diethyl-2-(4-hydroxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl)-N,N-diethylacetamide + ethyl ester of p-toluenesulfonic acid (80-40-0) → 2-(4-(3-(2-(diethylamino)-2-oxoethyl)-5,7-diethylpyrazolo[1,5-a]pyrimidin-2-yl)phenoxy)ethyl 4-methylbenzenesulfonate (1428949-92-1)

Guidance literature:

2-(5,7-diethyl-2-(4-hydroxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl)-N,N-diethylacetamide; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.333333h;

ethyl ester of p-toluenesulfonic acid; In tetrahydrofuran; at 30 ℃; for 26h;

Reference yield:

2-(5,7-diethyl-2-(4-hydroxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl)-N,N-diethylacetamide + 2-fluoroethyl tosylate (383-50-6) → 2-(4-(3-(2-(diethylamino)-2-oxoethyl)-5,7-diethylpyrazolo[1,5-a]pyrimidin-2-yl)phenoxy)ethyl 4-methylbenzenesulfonate (1428949-92-1)

Guidance literature:

2-(5,7-diethyl-2-(4-hydroxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl)-N,N-diethylacetamide; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 0.166667h; Microwave irradiation;

2-fluoroethyl tosylate; In tetrahydrofuran; at 120 ℃; for 0.5h; Microwave irradiation;

DOI:10.1021/jm4001874

Reference yield:

2-(5,7-diethyl-2-(4-hydroxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl)-N,N-diethylacetamide + 1,2-bis-tosyloxyethane (6315-52-2) → 2-(4-(3-(2-(diethylamino)-2-oxoethyl)-5,7-diethylpyrazolo[1,5-a]pyrimidin-2-yl)phenoxy)ethyl 4-methylbenzenesulfonate (1428949-92-1)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 120 ℃; for 0.666667h; Microwave irradiation;

upstream raw materials:

3-oxo-3-(4'-methoxyphenyl)propanenitrile

2-Chloro-N,N-diethylacetamide

2-fluoroethyl tosylate

N,N-diethyl-[3-cyano-4-(4-methoxyphenyl)-4-oxo]butanamide

Downstream raw materials:

C₂₄H₃₁⁽¹⁸⁾FN₄O₂