methyl 1-benzoyl-1,2,2a,3,4,5-hexahydro-5-oxo-benzindol-4-ylcarbamate

Base Information

Chemical Name:methyl 1-benzoyl-1,2,2a,3,4,5-hexahydro-5-oxo-benzindol-4-ylcarbamate
CAS No.:154139-58-9
Molecular Formula:C₂₀H₁₈N₂O₄
Molecular Weight:350.374
Hs Code.:

methyl 1-benzoyl-1,2,2a,3,4,5-hexahydro-5-oxo-benz<cd>indol-4-ylcarbamate

Synonyms:methyl 1-benzoyl-1,2,2a,3,4,5-hexahydro-5-oxo-benzindol-4-ylcarbamate

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Chemical Property of methyl 1-benzoyl-1,2,2a,3,4,5-hexahydro-5-oxo-benzindol-4-ylcarbamate

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Technology Process of methyl 1-benzoyl-1,2,2a,3,4,5-hexahydro-5-oxo-benzindol-4-ylcarbamate

There total 5 articles about methyl 1-benzoyl-1,2,2a,3,4,5-hexahydro-5-oxo-benzindol-4-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 80917-53-9
4-amino-1-benzoyl-2,2a,3,4-tetrahydrobenzindol-5(1H)-one hydrochloride

: 79-22-1
methyl chloroformate

: 154139-58-9
methyl 1-benzoyl-1,2,2a,3,4,5-hexahydro-5-oxo-benzindol-4-ylcarbamate

Guidance literature:: With triethylamine; In dichloromethane; at 12 ℃; for 0.75h;
DOI:10.1016/S0040-4020(01)80221-0

Reference yield:

: 132008-45-8,51867-02-8
1-benzoyl-2,2a,3,4-tetrahydro-1H-benz[cd]indol-5-one

: 154139-58-9
methyl 1-benzoyl-1,2,2a,3,4,5-hexahydro-5-oxo-benzindol-4-ylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / trimethylphenylammonium tribromide / tetrahydrofuran / 0.5 h / 0 °C

2: 92 percent / NaN₃ / acetic acid; dimethylformamide / 0 °C

3: 90 percent / H₂ / 10percent Pd/C / acetic acid / 1 h / 3102.9 Torr

4: 85 percent / Et₃N / CH₂Cl₂ / 0.75 h / 12 °C

With sodium azide; Trimethylphenylammonium tribromide; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)80221-0

Reference yield:

: 51867-03-9
4-bromo-1-benzoyl-2,2a,3,4-tetrahydrobenzindol-5-(1H)-one

: 154139-58-9
methyl 1-benzoyl-1,2,2a,3,4,5-hexahydro-5-oxo-benzindol-4-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / NaN₃ / acetic acid; dimethylformamide / 0 °C

2: 90 percent / H₂ / 10percent Pd/C / acetic acid / 1 h / 3102.9 Torr

3: 85 percent / Et₃N / CH₂Cl₂ / 0.75 h / 12 °C

With sodium azide; hydrogen; triethylamine; palladium on activated charcoal; In dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)80221-0