Cbz-leucylprolyl-L-(3-carboxy-1,2,3,4-tetrahydro-7-methoxyisoquinoline)-O-Boc-threonine

Base Information

Chemical Name:Cbz-leucylprolyl-L-(3-carboxy-1,2,3,4-tetrahydro-7-methoxyisoquinoline)-O-Boc-threonine
CAS No.:383910-58-5
Molecular Formula:C₃₉H₅₂N₄O₁₁
Molecular Weight:752.862
Hs Code.:

Synonyms:Cbz-leucylprolyl-L-(3-carboxy-1,2,3,4-tetrahydro-7-methoxyisoquinoline)-O-Boc-threonine

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Chemical Property of Cbz-leucylprolyl-L-(3-carboxy-1,2,3,4-tetrahydro-7-methoxyisoquinoline)-O-Boc-threonine

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Technology Process of Cbz-leucylprolyl-L-(3-carboxy-1,2,3,4-tetrahydro-7-methoxyisoquinoline)-O-Boc-threonine

There total 7 articles about Cbz-leucylprolyl-L-(3-carboxy-1,2,3,4-tetrahydro-7-methoxyisoquinoline)-O-Boc-threonine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 383910-57-4
Cbz-leucylprolyl-L-(3-carboxy-1,2,3,4-tetrahydro-7-methoxy-isoquinoline)-O-Boc-threonine-OSEM

: 383910-58-5
Cbz-leucylprolyl-L-(3-carboxy-1,2,3,4-tetrahydro-7-methoxyisoquinoline)-O-Boc-threonine

Guidance literature:: With magnesium bromide; In dichloromethane; at 0 ℃; for 3h;
DOI:10.1021/jo0105991

Reference yield:

: 126587-71-1
Boc-threonine [(2-trimethylsilyl)ethoxy]methyl ester

: 383910-58-5
Cbz-leucylprolyl-L-(3-carboxy-1,2,3,4-tetrahydro-7-methoxyisoquinoline)-O-Boc-threonine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 78 percent / Et₃N; DMAP; isopropenyl chloroformate / CH₂Cl₂ / 1.5 h / 0 °C

2.1: H₂ / Pd/C / methanol; ethyl acetate / 5 h / 2585.81 Torr

3.1: BOP-Cl; NMM / CH₂Cl₂ / 0.75 h / -15 - 0 °C

3.2: 2.90 g / NMM / CH₂Cl₂ / 6 h / 0 °C

4.1: MgBr₂ / CH₂Cl₂ / 3 h / 0 °C

With 4-methyl-morpholine; dmap; Isopropenyl chloroformate; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; magnesium bromide; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate;
DOI:10.1021/jo0105991

Reference yield:

: 383910-54-1
N-Cbz-L-1,2,3,4-tetrahydro-7-methoxyisoquinoline-3-carboxylic acid

: 383910-58-5
Cbz-leucylprolyl-L-(3-carboxy-1,2,3,4-tetrahydro-7-methoxyisoquinoline)-O-Boc-threonine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 78 percent / Et₃N; DMAP; isopropenyl chloroformate / CH₂Cl₂ / 1.5 h / 0 °C

2.1: H₂ / Pd/C / methanol; ethyl acetate / 5 h / 2585.81 Torr

3.1: BOP-Cl; NMM / CH₂Cl₂ / 0.75 h / -15 - 0 °C

3.2: 2.90 g / NMM / CH₂Cl₂ / 6 h / 0 °C

4.1: MgBr₂ / CH₂Cl₂ / 3 h / 0 °C

With 4-methyl-morpholine; dmap; Isopropenyl chloroformate; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; magnesium bromide; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate;
DOI:10.1021/jo0105991