((1S,2R)-1-Benzyl-3-cyano-2-hydroxy-propyl)-methyl-carbamic acid tert-butyl ester

Base Information

Chemical Name:((1S,2R)-1-Benzyl-3-cyano-2-hydroxy-propyl)-methyl-carbamic acid tert-butyl ester
CAS No.:260562-79-6
Molecular Formula:C₁₇H₂₄N₂O₃
Molecular Weight:304.389
Hs Code.:

Synonyms:((1S,2R)-1-Benzyl-3-cyano-2-hydroxy-propyl)-methyl-carbamic acid tert-butyl ester

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Chemical Property of ((1S,2R)-1-Benzyl-3-cyano-2-hydroxy-propyl)-methyl-carbamic acid tert-butyl ester

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Technology Process of ((1S,2R)-1-Benzyl-3-cyano-2-hydroxy-propyl)-methyl-carbamic acid tert-butyl ester

There total 5 articles about ((1S,2R)-1-Benzyl-3-cyano-2-hydroxy-propyl)-methyl-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 78571-81-0,81096-89-1,85531-71-1,99883-80-4,128575-26-8,116949-62-3
(R,R)-3-(phenylmethyl)oxiranemethanol

: 260562-79-6
((1S,2R)-1-Benzyl-3-cyano-2-hydroxy-propyl)-methyl-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: Ti(iPrO)2(N₃)2 / benzene / 75 °C

2: 77 percent / H₂ / 10 percent Pd/C / ethyl acetate / 20 °C / 760 Torr

3: 75 percent / PPh₃; DEAD / CHCl₃ / Heating

4: NaH / tetrahydrofuran / 0 °C

5: NEt₃ / tetrahydrofuran / Heating

With diisopropoxytitanium diazide; hydrogen; sodium hydride; triethylamine; triphenylphosphine; diethylazodicarboxylate; 10% palladium on active carbon; In tetrahydrofuran; chloroform; ethyl acetate; benzene; 1: Ring cleavage / 2: Hydrogenation / 3: Mitsunobu cyclization / 4: Methylation / 5: Ring cleavage;
DOI:10.1016/S0040-4039(99)01953-X

Reference yield:

: 116949-67-8
(2S,3S)-2-azido-1-phenyl-butane-3,4-diol

: 260562-79-6
((1S,2R)-1-Benzyl-3-cyano-2-hydroxy-propyl)-methyl-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 77 percent / H₂ / 10 percent Pd/C / ethyl acetate / 20 °C / 760 Torr

2: 75 percent / PPh₃; DEAD / CHCl₃ / Heating

3: NaH / tetrahydrofuran / 0 °C

4: NEt₃ / tetrahydrofuran / Heating

With hydrogen; sodium hydride; triethylamine; triphenylphosphine; diethylazodicarboxylate; 10% palladium on active carbon; In tetrahydrofuran; chloroform; ethyl acetate; 1: Hydrogenation / 2: Mitsunobu cyclization / 3: Methylation / 4: Ring cleavage;
DOI:10.1016/S0040-4039(99)01953-X

Reference yield:

: 98760-08-8,98818-34-9,98818-35-0,103127-56-6,98737-29-2
(1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester

: 260562-79-6
((1S,2R)-1-Benzyl-3-cyano-2-hydroxy-propyl)-methyl-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: NaH / tetrahydrofuran / 0 °C

2: NEt₃ / tetrahydrofuran / Heating

With sodium hydride; triethylamine; In tetrahydrofuran; 1: Methylation / 2: Ring cleavage;
DOI:10.1016/S0040-4039(99)01953-X