4-[(4-chloro-2-methyl-phenyl)-(5-chloro-2-methyl-phenylamino)-methyl]-1-(5-cyano-2-methoxy-phenyl)-5-isopropyl-1H-pyrazole-3-carboxylic acid

Base Information

Chemical Name:4-[(4-chloro-2-methyl-phenyl)-(5-chloro-2-methyl-phenylamino)-methyl]-1-(5-cyano-2-methoxy-phenyl)-5-isopropyl-1H-pyrazole-3-carboxylic acid
CAS No.:1441756-22-4
Molecular Formula:C₃₀H₂₈Cl₂N₄O₃
Molecular Weight:563.483
Hs Code.:

Synonyms:4-[(4-chloro-2-methyl-phenyl)-(5-chloro-2-methyl-phenylamino)-methyl]-1-(5-cyano-2-methoxy-phenyl)-5-isopropyl-1H-pyrazole-3-carboxylic acid

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Chemical Property of 4-[(4-chloro-2-methyl-phenyl)-(5-chloro-2-methyl-phenylamino)-methyl]-1-(5-cyano-2-methoxy-phenyl)-5-isopropyl-1H-pyrazole-3-carboxylic acid

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Technology Process of 4-[(4-chloro-2-methyl-phenyl)-(5-chloro-2-methyl-phenylamino)-methyl]-1-(5-cyano-2-methoxy-phenyl)-5-isopropyl-1H-pyrazole-3-carboxylic acid

There total 11 articles about 4-[(4-chloro-2-methyl-phenyl)-(5-chloro-2-methyl-phenylamino)-methyl]-1-(5-cyano-2-methoxy-phenyl)-5-isopropyl-1H-pyrazole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1441756-29-1
4-[(4-chloro-2-methyl-phenyl)-(5-chloro-2-methyl-phenylamino)-methyl]-1-(5-cyano-2-methoxy-phenyl)-5-isopropyl-1H-pyrazole-3-carboxylic acid ethyl ester

: 1441756-22-4
4-[(4-chloro-2-methyl-phenyl)-(5-chloro-2-methyl-phenylamino)-methyl]-1-(5-cyano-2-methoxy-phenyl)-5-isopropyl-1H-pyrazole-3-carboxylic acid

Guidance literature:: With lithium hydroxide monohydrate; In 1,4-dioxane; water; at 50 ℃;

Reference yield:

: 64195-85-3
ethyl 2,4-dioxo-5-methylhexanoate

: 1441756-22-4
4-[(4-chloro-2-methyl-phenyl)-(5-chloro-2-methyl-phenylamino)-methyl]-1-(5-cyano-2-methoxy-phenyl)-5-isopropyl-1H-pyrazole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: toluene / 1 h / 110 °C / Inert atmosphere

2.1: bromine / dichloromethane / 3 h / 20 °C / Irradiation

3.1: potassium carbonate; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 80 °C / Inert atmosphere

4.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / 1,4-dioxane; water; tert-butyl alcohol / 20 h / 20 °C

4.2: 2 h / 20 °C

5.1: tetrahydrofuran / 0.25 h / -10 °C / Inert atmosphere

6.1: triethylamine; Methanesulfonic anhydride / dichloromethane / 1 h / 20 °C / Inert atmosphere

6.2: 1 h / 20 °C / Inert atmosphere

7.1: lithium hydroxide monohydrate / 1,4-dioxane; water / 50 °C

With osmium(VIII) oxide; bis(tri-t-butylphosphine)palladium⁽⁰⁾; lithium hydroxide monohydrate; bromine; potassium carbonate; 4-methylmorpholine N-oxide; triethylamine; Methanesulfonic anhydride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; toluene; tert-butyl alcohol;

Reference yield:

: 1441756-38-2
4-[(4-chloro-2-methyl-phenyl)-hydroxy-methyl]-1-(5-cyano-2-methoxy-phenyl)-5-isopropyl-1H-pyrazole-3-carboxylic acid ethyl ester

: 1441756-22-4
4-[(4-chloro-2-methyl-phenyl)-(5-chloro-2-methyl-phenylamino)-methyl]-1-(5-cyano-2-methoxy-phenyl)-5-isopropyl-1H-pyrazole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; Methanesulfonic anhydride / dichloromethane / 1 h / 20 °C / Inert atmosphere

1.2: 1 h / 20 °C / Inert atmosphere

2.1: lithium hydroxide monohydrate / 1,4-dioxane; water / 50 °C

With lithium hydroxide monohydrate; triethylamine; Methanesulfonic anhydride; In 1,4-dioxane; dichloromethane; water;