6-((1R,2S)-2-aminocyclohexylamino)-4-(4,6-dimethylpyridin-2-ylamino)pyridazine-3-carboxamide 2,2,2-trifluoroacetate

Base Information

Chemical Name:6-((1R,2S)-2-aminocyclohexylamino)-4-(4,6-dimethylpyridin-2-ylamino)pyridazine-3-carboxamide 2,2,2-trifluoroacetate
CAS No.:1446819-69-7
Molecular Formula:C₂HF₃O₂*C₁₈H₂₅N₇O
Molecular Weight:469.467
Hs Code.:

Synonyms:6-((1R,2S)-2-aminocyclohexylamino)-4-(4,6-dimethylpyridin-2-ylamino)pyridazine-3-carboxamide 2,2,2-trifluoroacetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-((1R,2S)-2-aminocyclohexylamino)-4-(4,6-dimethylpyridin-2-ylamino)pyridazine-3-carboxamide 2,2,2-trifluoroacetate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 6-((1R,2S)-2-aminocyclohexylamino)-4-(4,6-dimethylpyridin-2-ylamino)pyridazine-3-carboxamide 2,2,2-trifluoroacetate

There total 8 articles about 6-((1R,2S)-2-aminocyclohexylamino)-4-(4,6-dimethylpyridin-2-ylamino)pyridazine-3-carboxamide 2,2,2-trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1446792-19-3
tert-butyl (1S,2R)-2-(6-carbamoyl-5-(4,6-dimethylpyridin-2-ylamino)pyridazin-3-ylamino)cyclohexylcarbamate

: 76-05-1
trifluoroacetic acid

: 1446819-69-7
6-((1R,2S)-2-aminocyclohexylamino)-4-(4,6-dimethylpyridin-2-ylamino)pyridazine-3-carboxamide 2,2,2-trifluoroacetate

Guidance literature:: In dichloromethane; at 20 ℃; for 4316h;

Reference yield:

: 679406-03-2
4,6-Dichloro-pyridazine-3-carboxylic acid ethyl ester

: 1446819-69-7
6-((1R,2S)-2-aminocyclohexylamino)-4-(4,6-dimethylpyridin-2-ylamino)pyridazine-3-carboxamide 2,2,2-trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1: acetonitrile / 20 h / 140 °C / Sealed tube

2: ammonia / methanol / 16 h / 50 °C

3: 1-methyl-pyrrolidin-2-one / 72 h / 130 °C

4: dichloromethane / 4316 h / 20 °C

With ammonia; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; acetonitrile;

Reference yield:

: 1446792-14-8
ethyl 6-chloro-4-(4,6-dimethylpyridin-2-ylamino)pyridazine-3-carboxylate

: 1446819-69-7
6-((1R,2S)-2-aminocyclohexylamino)-4-(4,6-dimethylpyridin-2-ylamino)pyridazine-3-carboxamide 2,2,2-trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: ammonia / methanol / 16 h / 50 °C

2: 1-methyl-pyrrolidin-2-one / 72 h / 130 °C

3: dichloromethane / 4316 h / 20 °C

With ammonia; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane;