1-cyclohexyl-4-{[6-(3-furanyl)-8-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]carbonyl}-2-piperazinone

Base Information

Chemical Name:1-cyclohexyl-4-{[6-(3-furanyl)-8-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]carbonyl}-2-piperazinone
CAS No.:1284246-63-4
Molecular Formula:C₂₃H₂₃F₃N₄O₃
Molecular Weight:460.456
Hs Code.:

Synonyms:1-cyclohexyl-4-{[6-(3-furanyl)-8-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]carbonyl}-2-piperazinone

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Chemical Property of 1-cyclohexyl-4-{[6-(3-furanyl)-8-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]carbonyl}-2-piperazinone

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Technology Process of 1-cyclohexyl-4-{[6-(3-furanyl)-8-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]carbonyl}-2-piperazinone

There total 5 articles about 1-cyclohexyl-4-{[6-(3-furanyl)-8-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]carbonyl}-2-piperazinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1121057-06-4
1-(3-chloro-6-furan-3-yl)-8-trifluoromethyl-imidazo[1,2-a]pyridine-2-carboxylic acid

: 99976-73-5
1-cyclohexylpiperazin-2-one

: 1284246-63-4
1-cyclohexyl-4-{[6-(3-furanyl)-8-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]carbonyl}-2-piperazinone

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; for 2h;

Reference yield:

: 79456-34-1
5-bromo-3-(trifluoromethyl)pyridin-2-amine

: 1284246-63-4
1-cyclohexyl-4-{[6-(3-furanyl)-8-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]carbonyl}-2-piperazinone

Guidance literature:: Multi-step reaction with 4 steps

1: 3 h / 50 °C

2: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 2.25 h / 90 °C

3: water; lithium hydroxide monohydrate / tetrahydrofuran / 4.5 h

4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2 h

With potassium phosphate; lithium hydroxide monohydrate; water; N-ethyl-N,N-diisopropylamine; HATU; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 183610-70-0
2-amino-3-trifluoromethylpyridine

: 1284246-63-4
1-cyclohexyl-4-{[6-(3-furanyl)-8-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]carbonyl}-2-piperazinone

Guidance literature:: Multi-step reaction with 5 steps

1: N-Bromosuccinimide / N,N-dimethyl-formamide / 2 h / 20 °C

2: 3 h / 50 °C

3: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 2.25 h / 90 °C

4: water; lithium hydroxide monohydrate / tetrahydrofuran / 4.5 h

5: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2 h

With potassium phosphate; N-Bromosuccinimide; lithium hydroxide monohydrate; water; N-ethyl-N,N-diisopropylamine; HATU; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;