[4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-[1-(2-methoxyethyl)-7-trifluoromethoxy-1H-indol-3-yl]-methanone

Base Information

Chemical Name:[4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-[1-(2-methoxyethyl)-7-trifluoromethoxy-1H-indol-3-yl]-methanone
CAS No.:1313040-16-2
Molecular Formula:C₂₅H₂₇F₄N₃O₃
Molecular Weight:493.501
Hs Code.:

Synonyms:[4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-[1-(2-methoxyethyl)-7-trifluoromethoxy-1H-indol-3-yl]-methanone

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Chemical Property of [4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-[1-(2-methoxyethyl)-7-trifluoromethoxy-1H-indol-3-yl]-methanone

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Technology Process of [4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-[1-(2-methoxyethyl)-7-trifluoromethoxy-1H-indol-3-yl]-methanone

There total 13 articles about [4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-[1-(2-methoxyethyl)-7-trifluoromethoxy-1H-indol-3-yl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1313041-44-9
2,2,2-trifluoro-N-(4-fluoro-3-{1-[1-(2-methoxyethyl)-7-trifluoromethoxy-1 H-indole-3-carbonyl]-piperidin-4-yl}benzyl)acetamide

: 1313040-16-2
[4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-[1-(2-methoxyethyl)-7-trifluoromethoxy-1H-indol-3-yl]-methanone

Guidance literature:: With water; potassium carbonate; In methanol; at 20 ℃;

Reference yield:

: 202865-68-7
3-bromo-4-fluoro-benzylamine hydrochloride

: 1313040-16-2
[4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-[1-(2-methoxyethyl)-7-trifluoromethoxy-1H-indol-3-yl]-methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / isopropyl alcohol; water / 11 h / 10 - 80 °C

1.2: 5 °C

1.3: 10 °C

2.1: hydrogen / platinum on carbon / methanol / 20 °C / 517.16 - 3102.97 Torr

3.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

4.1: potassium carbonate; water / methanol / 20 °C

With water; hydrogen; sodium hydrogencarbonate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; platinum on carbon; In methanol; dichloromethane; water; isopropyl alcohol;

Reference yield:

: 1692-15-5
4-pyridylboronic acid

: 1313040-16-2
[4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-[1-(2-methoxyethyl)-7-trifluoromethoxy-1H-indol-3-yl]-methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / isopropyl alcohol; water / 11 h / 10 - 80 °C

1.2: 5 °C

1.3: 10 °C

2.1: hydrogen / platinum on carbon / methanol / 20 °C / 517.16 - 3102.97 Torr

3.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

4.1: potassium carbonate; water / methanol / 20 °C

With water; hydrogen; sodium hydrogencarbonate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; platinum on carbon; In methanol; dichloromethane; water; isopropyl alcohol;