(+/-)-N-(2-{3-[(E)-2-(7-chloro-2-quinolyl)vinyl]phenyl}-2-hydroxyethyl)phthalimide

Base Information

Chemical Name:(+/-)-N-(2-{3-[(E)-2-(7-chloro-2-quinolyl)vinyl]phenyl}-2-hydroxyethyl)phthalimide
CAS No.:203940-22-1
Molecular Formula:C₂₇H₁₉ClN₂O₃
Molecular Weight:454.912
Hs Code.:

Synonyms:(+/-)-N-(2-{3-[(E)-2-(7-chloro-2-quinolyl)vinyl]phenyl}-2-hydroxyethyl)phthalimide

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Chemical Property of (+/-)-N-(2-{3-[(E)-2-(7-chloro-2-quinolyl)vinyl]phenyl}-2-hydroxyethyl)phthalimide

Chemical Property:

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Technology Process of (+/-)-N-(2-{3-[(E)-2-(7-chloro-2-quinolyl)vinyl]phenyl}-2-hydroxyethyl)phthalimide

There total 1 articles about (+/-)-N-(2-{3-[(E)-2-(7-chloro-2-quinolyl)vinyl]phenyl}-2-hydroxyethyl)phthalimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 203940-21-0
(+/-)-2-amino-1-{3-[(E)-2-(7-chloro-2-quinolyl)vinyl]phenyl}ethanol

: 85-44-9
phthalic anhydride

: 203940-22-1
(+/-)-N-(2-{3-[(E)-2-(7-chloro-2-quinolyl)vinyl]phenyl}-2-hydroxyethyl)phthalimide

Guidance literature:: In toluene; at 160 ℃; for 3h; under 3 Torr;
DOI:10.1248/cpb.54.603

Reference yield:

: 203940-22-1
(+/-)-N-(2-{3-[(E)-2-(7-chloro-2-quinolyl)vinyl]phenyl}-2-hydroxyethyl)phthalimide

: 3-(2-Amino-1-{3-[(E)-2-(7-chloro-quinolin-2-yl)-vinyl]-phenyl}-ethylsulfanyl)-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 19.0 g / pyridine / 1,2-dichloro-ethane / 12 h / 20 °C

2: 15 percent / cesium carbonate / dimethylsulfoxide / 1 h / 20 °C

3: methylhydrazine / ethanol; dioxane / 7 h / Heating

With pyridine; caesium carbonate; methylhydrazine; In 1,4-dioxane; ethanol; dimethyl sulfoxide; 1,2-dichloro-ethane;
DOI:10.1248/cpb.54.603

Reference yield:

: 203940-22-1
(+/-)-N-(2-{3-[(E)-2-(7-chloro-2-quinolyl)vinyl]phenyl}-2-hydroxyethyl)phthalimide

: 4-(2-Amino-1-{3-[(E)-2-(7-chloro-quinolin-2-yl)-vinyl]-phenyl}-ethylsulfanyl)-3,3-dimethyl-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 19.0 g / pyridine / 1,2-dichloro-ethane / 12 h / 20 °C

2: 41 percent / cesium carbonate / dimethylsulfoxide / 1 h / 20 °C

3: methylhydrazine / ethanol; dioxane / 7 h / Heating

With pyridine; caesium carbonate; methylhydrazine; In 1,4-dioxane; ethanol; dimethyl sulfoxide; 1,2-dichloro-ethane;
DOI:10.1248/cpb.54.603