2,4-dichloro-5-{[4-(ethoxycarbonyl)piperidin-1-yl]sulfonyl}benzoic acid

Base Information

• Chemical Name: 2,4-dichloro-5-{[4-(ethoxycarbonyl)piperidin-1-yl]sulfonyl}benzoic acid
• CAS No.: 938016-80-9
• Molecular Formula: C₁₅H₁₇Cl₂NO₆S
• Molecular Weight: 410.275

Synonyms:2,4-dichloro-5-{[4-(ethoxycarbonyl)piperidin-1-yl]sulfonyl}benzoic acid

Chemical Property of 2,4-dichloro-5-{[4-(ethoxycarbonyl)piperidin-1-yl]sulfonyl}benzoic acid

Chemical Property:

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Technology Process of 2,4-dichloro-5-{[4-(ethoxycarbonyl)piperidin-1-yl]sulfonyl}benzoic acid

There total 2 articles about 2,4-dichloro-5-{[4-(ethoxycarbonyl)piperidin-1-yl]sulfonyl}benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

4-carbethoxypiperidine (1126-09-6) + 2,4-dichloro-5-(chlorosulfonyl)benzoic acid (3740-18-9) → 2,4-dichloro-5-{[4-(ethoxycarbonyl)piperidin-1-yl]sulfonyl}benzoic acid (938016-80-9)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.ejmech.2013.05.013

Reference yield:

2,4 dichlorobenzoic acid (50-84-0) → 2,4-dichloro-5-{[4-(ethoxycarbonyl)piperidin-1-yl]sulfonyl}benzoic acid (938016-80-9)

Guidance literature:

Multi-step reaction with 2 steps

1: chlorosulfonic acid / 16 h / 0 - 140 °C

2: triethylamine / dichloromethane / 0 - 20 °C

With chlorosulfonic acid; triethylamine; In dichloromethane;

DOI:10.1016/j.ejmech.2013.05.013

Reference yield:

2,4-dichloro-5-{[4-(ethoxycarbonyl)piperidin-1-yl]sulfonyl}benzoic acid (938016-80-9) → C15H16Cl3NO5S

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1016/j.ejmech.2013.05.013

upstream raw materials:

4-carbethoxypiperidine

2,4-dichloro-5-(chlorosulfonyl)benzoic acid

2,4 dichlorobenzoic acid

Downstream raw materials:

ethyl 1-((2,4-dichloro-5-((3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)carbamoyl)phenyl)sulfonyl)piperidine-4-carboxylate

1-((2,4-dichloro-5-((3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)carbamoyl)phenyl)sulfonyl)piperidine-4-carboxylic acid

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