diethyl 2-(4-(dimethylamino)phenyl)-1,1-difluoro-2-phenylethylphosphonate

Base Information

• Chemical Name: diethyl 2-(4-(dimethylamino)phenyl)-1,1-difluoro-2-phenylethylphosphonate
• CAS No.: 83567-75-3
• Molecular Formula: C₁₄H₂₂F₂NO₄P
• Molecular Weight: 337.304
• Mol file: 83567-75-3.mol

Synonyms:diethyl 2-(4-(dimethylamino)phenyl)-1,1-difluoro-2-phenylethylphosphonate

Chemical Property of diethyl 2-(4-(dimethylamino)phenyl)-1,1-difluoro-2-phenylethylphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl 2-(4-(dimethylamino)phenyl)-1,1-difluoro-2-phenylethylphosphonate

There total 4 articles about diethyl 2-(4-(dimethylamino)phenyl)-1,1-difluoro-2-phenylethylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

diethyl difluoromethylphosphonate lithium salt (94993-99-4,83567-74-2) + 4-dimethylamino-benzaldehyde (100-10-7) → diethyl 2-(4-(dimethylamino)phenyl)-1,1-difluoro-2-phenylethylphosphonate (83567-75-3)

Guidance literature:

In tetrahydrofuran; Ambient temperature;

DOI:10.1016/S0040-4039(00)87332-3

Reference yield: 70.0%

Diethyl difluoromethylphosphonate (1478-53-1) + 4-dimethylamino-benzaldehyde (100-10-7) → diethyl 2-(4-(dimethylamino)phenyl)-1,1-difluoro-2-phenylethylphosphonate (83567-75-3)

Guidance literature:

Diethyl difluoromethylphosphonate; With lithium diisopropyl amide; In tetrahydrofuran; at -74 ℃; for 0.5h; Inert atmosphere;

4-dimethylamino-benzaldehyde; In tetrahydrofuran; cyclohexane; at -74 ℃; for 4h; Inert atmosphere;

DOI:10.1016/j.tet.2008.10.006

Reference yield:

Diethyl difluoromethylphosphonate (1478-53-1) → diethyl 2-(4-(dimethylamino)phenyl)-1,1-difluoro-2-phenylethylphosphonate (83567-75-3)

Guidance literature:

Multi-step reaction with 2 steps

1: LDA / tetrahydrofuran / -78 °C

2: 71 percent / tetrahydrofuran / Ambient temperature

With lithium diisopropyl amide; In tetrahydrofuran;

DOI:10.1016/S0040-4039(00)87332-3

upstream raw materials:

diethyl difluoromethylphosphonate lithium salt

4-dimethylamino-benzaldehyde

diethyl (bromodifluoromethyl)phosphonate

Diethyl difluoromethylphosphonate

Downstream raw materials:

4-dimethylamino-β,β-difluorostyrene