5-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-9-ylmethyl]thiophen-3-carboxylic acid methyl ester hydrochloride salt

Base Information

Chemical Name:5-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-9-ylmethyl]thiophen-3-carboxylic acid methyl ester hydrochloride salt
CAS No.:882004-79-7
Molecular Formula:C₂₇H₂₂Cl₂N₄O₄S*ClH
Molecular Weight:605.929
Hs Code.:

5-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-9-ylmethyl]thiophen-3-carboxylic acid methyl ester hydrochloride salt

Synonyms:5-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-9-ylmethyl]thiophen-3-carboxylic acid methyl ester hydrochloride salt

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Chemical Property of 5-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-9-ylmethyl]thiophen-3-carboxylic acid methyl ester hydrochloride salt

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Technology Process of 5-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-9-ylmethyl]thiophen-3-carboxylic acid methyl ester hydrochloride salt

There total 1 articles about 5-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-9-ylmethyl]thiophen-3-carboxylic acid methyl ester hydrochloride salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 4-[(5S,9R)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-9-yl]benzonitrile semi (+)-DTTA salt

: 67808-66-6
3-methoxycarbonyl-thiophene-5-carboxaldehyde

: 882004-79-7
5-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-9-ylmethyl]thiophen-3-carboxylic acid methyl ester hydrochloride salt

Guidance literature:: 4-[(5S,9R)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-9-yl]benzonitrile semi (+)-DTTA salt; 3-methoxycarbonyl-thiophene-5-carboxaldehyde; With acetic acid; triethylamine; In tetrahydrofuran; at 20 - 25 ℃; Inert atmosphere; Large scale reaction;

With triacetoxy sodium borohydride; In tetrahydrofuran; at 15 - 25 ℃; for 8h; Inert atmosphere; Large scale reaction;

With hydrogenchloride; In water; isopropyl alcohol; at 20 - 70 ℃; for 6h; Inert atmosphere; Large scale reaction;
DOI:10.1021/op9003168

Reference yield: 91.5%

: 882004-79-7
5-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-9-ylmethyl]thiophen-3-carboxylic acid methyl ester hydrochloride salt

: BMS-587101

Guidance literature:: With propylene glycol; potassium hydroxide; In tetrahydrofuran; water; at 8 - 12 ℃; Inert atmosphere; Large scale reaction;
DOI:10.1021/op9003168