Technology Process of 5-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-9-ylmethyl]thiophen-3-carboxylic acid methyl ester hydrochloride salt
There total 1 articles about 5-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-9-ylmethyl]thiophen-3-carboxylic acid methyl ester hydrochloride salt which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-[(5S,9R)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-9-yl]benzonitrile semi (+)-DTTA salt; 3-methoxycarbonyl-thiophene-5-carboxaldehyde;
With
acetic acid; triethylamine;
In
tetrahydrofuran;
at 20 - 25 ℃;
Inert atmosphere;
Large scale reaction;
With
triacetoxy sodium borohydride;
In
tetrahydrofuran;
at 15 - 25 ℃;
for 8h;
Inert atmosphere;
Large scale reaction;
With
hydrogenchloride;
In
water; isopropyl alcohol;
at 20 - 70 ℃;
for 6h;
Inert atmosphere;
Large scale reaction;
DOI:10.1021/op9003168
- Guidance literature:
-
With
propylene glycol; potassium hydroxide;
In
tetrahydrofuran; water;
at 8 - 12 ℃;
Inert atmosphere;
Large scale reaction;
DOI:10.1021/op9003168
![4-[(5S,9R)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-9-yl]benzonitrile semi (+)-DTTA salt](/Databaselist/images/loading.webp)
