2-(p-hydroxyphenylpropionoyloxy)(a)-4-(3',4'-dimethoxyphenyl)(e)-trans-quinolizidine

Base Information

• Chemical Name: 2-(p-hydroxyphenylpropionoyloxy)(a)-4-(3',4'-dimethoxyphenyl)(e)-trans-quinolizidine
• CAS No.: 77092-63-8
• Molecular Formula: C₂₆H₃₃NO₅
• Molecular Weight: 439.552
• Mol file: 77092-63-8.mol

Synonyms:2-(p-hydroxyphenylpropionoyloxy)(a)-4-(3',4'-dimethoxyphenyl)(e)-trans-quinolizidine

Chemical Property of 2-(p-hydroxyphenylpropionoyloxy)(a)-4-(3',4'-dimethoxyphenyl)(e)-trans-quinolizidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(p-hydroxyphenylpropionoyloxy)(a)-4-(3',4'-dimethoxyphenyl)(e)-trans-quinolizidine

There total 14 articles about 2-(p-hydroxyphenylpropionoyloxy)(a)-4-(3',4'-dimethoxyphenyl)(e)-trans-quinolizidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

C33H37NO5 → 2-(p-hydroxyphenylpropionoyloxy)(a)-4-(3',4'-dimethoxyphenyl)(e)-trans-quinolizidine (77092-63-8)

Guidance literature:

With palladium on carbon; hydrogen; In ethyl acetate; for 6h; Inert atmosphere;

DOI:10.1021/ol3015573

Reference yield: 64.0%

2-(p-benzyloxyphenylpropionoyloxy)(a)-4-(3',4'-dimethoxyphenyl)(e)-trans-quinolizidine (77092-60-5) → 2-(p-hydroxyphenylpropionoyloxy)(a)-4-(3',4'-dimethoxyphenyl)(e)-trans-quinolizidine (77092-63-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1016/0040-4020(80)85040-X

Reference yield:

(2S,9aS)-4-(3,4-Dimethoxy-phenyl)-octahydro-quinolizin-2-ol (68622-77-5,68681-73-2,71656-68-3,88931-04-8,88931-05-9,89771-49-3,149563-95-1) → 2-(p-hydroxyphenylpropionoyloxy)(a)-4-(3',4'-dimethoxyphenyl)(e)-trans-quinolizidine (77092-63-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 61 percent / sodium hydride / xylene / 6 h / Heating

2: 64 percent / H₂ / 10percent Pd-C / ethanol

With hydrogen; sodium hydride; palladium on activated charcoal; In ethanol; xylene;

DOI:10.1016/0040-4020(80)85040-X

upstream raw materials:

2-(p-benzyloxyphenylpropionoyloxy)(a)-4-(3',4'-dimethoxyphenyl)(e)-trans-quinolizidine

(2S,9aS)-4-(3,4-Dimethoxy-phenyl)-octahydro-quinolizin-2-ol

methyl 3-(4-benzyloxyphenyl)propanoate

piperidine

Downstream raw materials:

2-(p-benzyloxyphenylpropionoyloxy)(a)-4-(3',4'-dimethoxyphenyl)(e)-trans-quinolizidine

Decinin

2-(p-methoxyphenylpropionoyloxy)(a)-4-(3',4'-dimethoxyphenyl)(e)-trans-quinolizidine